Results: 9

O efeito do tratamento com rapamicina em órgãos linfoides de camundongos propensos à senescência acelerada

Envelhecer compreende um fenômeno complexo, natural e irreversível, que submete o organismo a inúmeras alterações nos processos biológicos, fisiológicos, ambientais, psicológicos, comportamentais e sociais. Esse processo é caracterizado por um declínio gradual dos mecanismos homeostáticos do o...

Reduced naïve T cell numbers correlate with increased low-grade systemic inflammation during ageing and can be modulated by physical activity

Int. j. morphol; 39 (3), 2021
SUMMARY: Age-associated decline of immune system, termed immunosenescence, is characterized by low-grade systemic inflammation, known as inflammaging, together with T-cell functional dysregulation. Although affecting all individuals, different environmental as well genetic factors impinge on the individu...

Respuesta inmune y alergia a vacunas

Rev. Méd. Clín. Condes; 31 (3/4), 2020
Las vacunas son altamente efectivas en prevenir enfermedades infecciosas a través del desarrollo en el individuo de una respuesta inmune protectora, sin desarrollar la enfermedad. Los distintos tipos de vacunas producen diferentes tipos de respuestas inmunes y variadas estrategias se han desarrollado pa...

Effects of natural aging and gender on pro-inflammatory markers

Braz. j. med. biol. res; 52 (9), 2019
The term inflammaging is now widely used to designate the inflammatory process of natural aging. During this process, cytokine balance is altered, presumably due to the loss of homeostasis, thus contributing to a greater predisposition to disease and exacerbation of chronic diseases. The aim of the study...

Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes

Einstein (Säo Paulo); 17 (2), 2019
ABSTRACT Healthy aging is partly related to appropriate function of the immune system. As already reported, some changes in this system are observed, including reduced number and repertoire of T cells due to thymic involution, accumulation of memory T cells by chronic infections, homeostatic proliferatio...

Manipulación de la inmunosenescencia
Immunosenescence manipulation

En la actualidad existe un aumento del envejecimiento poblacional en Cuba y a nivel mundial, consecuencia del éxito de las políticas de salud pública y del desarrollo socioeconómico. Con el incremento progresivo de la edad se evidencian cambios en el sistema inmunológico que contribuyen a una suscep...

Association between inflammatory mediators, grip strength and mobility in community-dwelling elderly

Abstract Introduction: Aging is associated with loss of muscle mass, immunosenescence and increased production of inflammatory mediators, high levels being predictors of a decline in functional capacity in the elderly. Objective: To assess the association between inflammatory mediators, interleukin 6...

Immune System Dysfunction in the Elderly

An. acad. bras. ciênc; 89 (1), 2017
ABSTRACT Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated...

ASMA EN ADULTOS MAYORES

El asma se ha considerado a menudo como una enfermedad cuyo inicio se produce en la infancia. Sin embargo, recientes estudios poblacionales han informado que el inicio del asma es común en las personas mayores. La carga sanitaria, personal y económica del asma puede ser más significativa en los ancian...