Results: 5

Synergistic Renoprotective Effects of Green Tea Extract and Gemigliptin against Tacrolimus-Induced Nephrotoxicity in Mice

Int. j. morphol; 42 (2), 2024
SUMMARY: Although tacrolimus (TAC) significantly reduces allograft rejection incidence in solid-organ transplantation, its long-term use is associated with an increased risk of TAC-induced nephrotoxicity. In this study, we investigated the renoprotective effects of green tea extract (GTE) with or without...

Hepatotoxicidade induzida por azatioprina em portadora da síndrome de Vogt-Koyanagi-Harada

Este relato teve como objetivo apresentar um caso de hepatotoxicidade colestática induzida por azatioprina em portadora da síndrome de Vogt-Koyanagi-Harada. À admissão, apresentava icterícia +3/+4, acolia fecal e colúria, além de aumento de marcadores hepáticos, sendo compatível com síndrome ...

Endothelin-1 receptor antagonists protect the kidney against the nephrotoxicity induced by cyclosporine-A in normotensive and hypertensive rats

Braz. j. med. biol. res; 51 (2), 2018
Cyclosporin-A (CsA) is an immunosuppressant associated with acute kidney injury and chronic kidney disease. Nephrotoxicity associated with CsA involves the increase in afferent and efferent arteriole resistance, decreased renal blood flow (RBF) and glomerular filtration. The aim of this study was to eval...

Avaliaçäo da funçäo tubular proximal utilizando o clearance de lítio no tratamento pela ciclosporina A em ratos
Evaluation of the proximal tubular function using the clearance of the lithium in the treatment by cyclosporine A in rats

J. bras. nefrol; 19 (4), 1997
Estudamos as alteraçöes renais como o uso da CSA (12,5 mg/kg/d/6 semanas), em ratos Wistar Nx à direita (G1 = controle, n = 12) (G2 = CSA, n = 12). Foram realizados clearances de creatinina (Ccr), lítio (CLi) e estudo histopatológico do rim E. Os resultados näo mostraram alteraçao significativa no...