Results: 3

Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs

J. bras. nefrol; 41 (1), 2019
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used medications associated with nephrotoxicity, especially when used chronically. Factors such as advanced age and comorbidities, which in themselves already lead to a decrease in glomerular filtration rate, increase the risk of NSAID-...

The relationship between proton pump inhibitors and renal disease

J. bras. nefrol; 40 (3), 2018
ABSTRACT Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have found tha...