Skeletal muscle is an important metabolic tissue in glucose uptake and thus in glycemic homeostasis. Evidence suggests that phenolic compounds may exert beneficial health effects against metabolic disorders associated to obesity including its state of peripheral insulin resistance. The objective of this ...
Diabetes mellitus is a serious disease with a high incidence of occurrence in our community. Gum Arabic (GA) is a branched-chain polysaccharide which has strong antioxidant properties, and has been used to reduce the experimental toxicity. Yet, the effects of GA on testicular tissue in type I diabetic ra...
Abstract Purpose Given the high prevalence of diabetes (D), several animal models have been analyzed. In the literature, most of the animal models have studied severe D. However, in clinical practice, most patients have moderate disease. Therefore, the present study aimed to describe a moderate D condi...
Vanadyl sulfate (VS) is an ingredient in some food supplements and experimental drugs. This study was designed to assay the effects of VS on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2. 30 male Wistar rats were divided into three equal groups as follow: no...
Biomarcadores/análisis,
Estrés Oxidativo/inmunología,
Diabetes Mellitus Tipo 2/patología,
Interleucina-1/antagonistas & inhibidores,
Interleucina-10/antagonistas & inhibidores,
Insulina/farmacología,
Preparaciones Farmacéuticas/administración & dosificación,
Secreción de Insulina,
Sulfatos/análisis,
Vanadatos/análisis,
Suplementos Dietéticos/efectos adversos
Hormones regulate hepatic gene expressions to maintain metabolic homeostasis. Ectonucleotide pyrophosphatase/phosphodiesterase 1 has been thought to interfere with insulin signaling. To determine its potential role in the regulation of metabolism, we analyzed its gene (Enpp1) expression in the liver of r...
Dexametasona/farmacología,
Inducción Enzimática/efectos de los fármacos,
Ayuno/metabolismo,
Regulación Enzimológica de la Expresión Génica/efectos de los fármacos,
Glucocorticoides/farmacología,
Células Hep G2,
Hipoglucemiantes/farmacología,
Insulina/farmacología,
Resistencia a la Insulina,
Hígado/enzimología,
Hidrolasas Diéster Fosfóricas/biosíntesis,
Hidrolasas Diéster Fosfóricas/efectos de los fármacos,
Hidrolasas Diéster Fosfóricas/genética,
Pirofosfatasas/biosíntesis,
Pirofosfatasas/efectos de los fármacos,
Pirofosfatasas/genética,
ARN Mensajero/efectos de los fármacos,
ARN Mensajero/metabolismo,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa
ABSTRACT Introduction/Aim: The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones secretion influencing insulin metabolism. In diabetic rats, oral insulin has potential to change intestinal epithelium be...
Ratas Wistar,
Pérdida de Peso/efectos de los fármacos,
Radioinmunoensayo,
Lípidos/sangre,
Insulina/farmacología,
Insulina/administración & dosificación,
Hipoglucemiantes/farmacología,
Hipoglucemiantes/administración & dosificación,
Dieta Alta en Grasa,
Glucemia/efectos de los fármacos,
Glucemia/análisis
Abstract Background: Resistance exercise (RE) has been recommended for patients with cardiovascular diseases. Recently, a few studies have demonstrated that the intensity of a single bout of RE has an effect on endothelial adaptations to exercise. However, there is no data about the effects of different...
Endotelio Vascular/efectos de los fármacos,
Endotelio Vascular/fisiología,
Factores Relajantes Endotelio-Dependientes/fisiología,
Inhibidores Enzimáticos/farmacología,
Insulina/farmacología,
Arterias Mesentéricas/efectos de los fármacos,
Arterias Mesentéricas/fisiología,
NG-Nitroarginina Metil Éster/farmacología,
Óxido Nítrico/fisiología,
Condicionamiento Físico Animal/fisiología,
Distribución Aleatoria,
Ratas Wistar,
Entrenamiento de Fuerza,
Vasodilatación/efectos de los fármacos,
Vasodilatadores/farmacología
RESUMO Objetivo: descrever o processo de construção de uma cartilha educativa sobre insulinoterapia para crianças com diabetes mellitus tipo 1. Método: abordagem metodológica, na qual se seguiram as etapas: seleção do conteúdo e tipo de tecnologia a ser construída (para essa etapa, foi realiza...
ABSTRACT Purpose: The goal of the present study was to establish a protocol for primary culture of lacrimal gland acinar cells (LGACs) and to assess the effect of adding insulin to the culture media. Methods: LGACs were isolated and cultured from lacrimal glands of Wistar male rats. The study outcomes ...
Células Acinares/citología,
Células Acinares/efectos de los fármacos,
Células Acinares/metabolismo,
Carbacol/metabolismo,
Recuento de Células/métodos,
Separación Celular/métodos,
Insulina/metabolismo,
Insulina/farmacología,
Aparato Lagrimal/citología,
Aparato Lagrimal/metabolismo,
Peroxidasa/metabolismo,
Cultivo Primario de Células/normas,
Ratas Wistar
Presentamos a consideración una revisión sobre el manejo prioritario de los pacientes diabeticos sometidos a cirugia electiva: menor, mediana o mayor y cirugia de urgencia. La evaluación sistematizada debe realizarse en base a una historia clinica completa: anammesis exploración física, exámenes co...
