Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells
J. venom. anim. toxins incl. trop. dis; 24 (), 2018
Background: Matrix metalloproteinases (MMPs) are key players in tumor progression, helping tumor cells to modify their microenvironment, which allows cell migration to secondary sites. The role of integrins, adhesion receptors that connect cells to the extracellular matrix, in MMP expression and activity...
Metaloproteinasa 9 de la Matriz/farmacología, Metaloproteinasa 2 de la Matriz/farmacología, Neoplasias de la Mama, Células Endoteliales, Venenos de Crotálidos/farmacología, Integrina alfa2beta1/metabolismo, Bothrops, Receptores de Colágeno, Microambiente Tumoral, Reacción en Cadena de la Polimerasa/métodos, Western Blotting/métodos, Citometría de Flujo