Results: 2

Effect of Lyophilization on Stability of PEG-Protein Conjugate: A Case Study with Peginterferon alfa-2b

Chintan, Patel; Gayatri, Patel.

Braz. J. Pharm. Sci. (Online); 59 (), 2023

Abstract The purpose of the present study was to develop stable lyophilized formulation of peginterferon alfa-2b which is acquiescent to the short lyophilization process. The present study evaluates the effect of buffering components and cryoprotectant(s) on depegylation of the peginterferon alfa-2b in c...

Liofilización/métodos, Cromatografía en Gel/métodos, Antivirales/efectos adversos, Preparaciones Farmacéuticas/análisis, d0077850, Interferón alfa-2/farmacología

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Ocular surface findings in impression cytology after interferon a2b or mitomycin C in rabbits

Almeida, Simone Ribeiro Araújo de; Martins, Maria Cristina; Barros, Jeison de Nadai; Lowen, Marcia Serva; Alves Júnior, Milton; Burnier Jr, Miguel N.

Rev. bras. oftalmol; 80 (4), 2021

ABSTRACT Objective: To describe ocular surface findings in impression cytology obtained from healthy rabbit conjunctiva treated with interferon alpha-2b eyedrop, and compare them to findings after use of mitomycin C 0.02%. Methods: An experimental study using a rabbit model was performed between Septem...

Conjuntiva/citología, Técnicas Citológicas, Citodiagnóstico/métodos, Conjuntiva/efectos de los fármacos, Conjuntiva/ultraestructura, Celulosa, Filtros Microporos, Neoplasias de la Conjuntiva/tratamiento farmacológico, Carcinoma de Células Escamosas/tratamiento farmacológico, Mitomicina/uso terapéutico, Mitomicina/farmacología, Interferón alfa-2/uso terapéutico, Interferón alfa-2/farmacología, Técnicas de Cultivo de Célula, Córnea/citología, Córnea/efectos de los fármacos, Córnea/ultraestructura

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