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Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism

Carneiro, Valdirene Leão; Bendicho, Maria Teresita; Santos, Rosalina Guedes; Casela, Marilda; Netto, Eduardo M; Mota, Scarlet Torres Moraes; Pina, Iza Cristina Araújo; Nascimento, Roberto Meyer; Freire, Songeli Menezes; Barbosa, Theolis.
Braz. j. infect. dis; 22 (3), 2018
ABSTRACT Introduction Latent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ produc...
Estudios de Casos y Controles, Brasil, Frecuencia de los Genes, Genotipo, Técnicas de Genotipaje, Interferón gamma/genética, Interferón gamma/metabolismo, Ensayos de Liberación de Interferón gamma/métodos, Mycobacterium tuberculosis/genética, Polimorfismo Genético/genética, Reproducibilidad de los Resultados, Sensibilidad y Especificidad, Estadísticas no Paramétricas, Prueba de Tuberculina, Tuberculosis Pulmonar/diagnóstico
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Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil

Alvarado-Arnez, Lucia Elena; Batista, Angelica Martins; Alves, Silvia Marinho; Melo, Gloria; Lorena, Virgínia Maria Barros de; Cardoso, Cynthia C; Pereira, Isabela Resende; Carrazzone, Cristina; Pacheco, Antonio G; Oliveira Jr, Wilson; Moraes, Milton Ozório; Lannes-Vieira, Joseli.
Mem. Inst. Oswaldo Cruz; 113 (6), 2018
BACKGROUND The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necr...
Cardiomiopatía Chagásica/complicaciones, Estudios de Casos y Controles, Citocinas/genética, Predisposición Genética a la Enfermedad, Interferón gamma/genética, Polimorfismo de Nucleótido Simple, Receptores Tipo I de Factores de Necrosis Tumoral
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Concordance between IFNγ gene +874 A/T polymorphism and interferon-γ expression in a TB-endemic indigenous setting

Araujo, Zaida; Palacios, Andrea; Biomon, Rubén; Rivas-Santiago, Bruno; Serrano, Carmen Judith; Enciso-Moreno, Leonor; López-Ramos, Juan Ernesto; Wide, Albina; Jiménez, Juan Carlos; Larrea, Carlos Fernández de; Enciso-Moreno, José Antonio.
Rev. Soc. Bras. Med. Trop; 50 (2), 2017
Abstract INTRODUCTION: Interferon-γ (IFN-γ) plays a crucial role in resistance to mycobacterial diseases; accordingly, variants of the gene encoding this cytokine may be associated with elevated risk of contracting pulmonary tuberculosis (TB). METHODS: Blood samples were collected from 135 W...
Estudios Transversales, Enfermedades Endémicas, Genotipo, Indígenas Sudamericanos/estadística & datos numéricos, Interferón gamma/genética, Interferón gamma/metabolismo, Persona de Mediana Edad, Reacción en Cadena de la Polimerasa, Polimorfismo Genético/genética, Prueba de Tuberculina, Tuberculosis Pulmonar/diagnóstico, Tuberculosis Pulmonar/epidemiología, Tuberculosis Pulmonar/etnología, Venezuela/epidemiología
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