Protection mediated by chemokine CXCL10 in BALB/c mice infected by Leishmania infantum
Mem. Inst. Oswaldo Cruz; 112 (8), 2017
BACKGROUND Visceral leishmaniasis (VL) caused by Leishmania infantum is characterised by the loss of the ability of the host to generate an effective immune response. Chemokines have a direct involvement in the pathogenesis of leishmaniasis, causing a rapid change in the expression of these molecules du...
Quimiocina CXCL10/uso terapéutico, Citocinas/inmunología, Interferón gamma/análisis, Interleucina-10/biosíntesis, Interleucina-4/biosíntesis, Leishmania infantum, Leishmaniasis Visceral/tratamiento farmacológico, Leishmaniasis Visceral/inmunología, Leishmaniasis Visceral/parasitología, Hígado/patología, Macrófagos/efectos de los fármacos, Ratones Endogámicos BALB C, Tamaño de los Órganos/fisiología