LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Therapeutic effects of benzoylaconitine and paeoniflorin in rats with collagen-induced arthritis

Li, Jie; Gu, Ping; Tong, Rong-Sheng; Wang, JiaFeng; Zhang, ShuHan; He, Dan; Li, Jin-Qi.

Braz. J. Pharm. Sci. (Online); 58 (), 2022

Abstract To explore the effects and mechanisms of benzoylaconitine and paeoniflorin on collagen-induced arthritis (CIA) rats. Weight, paw swelling, arthritis index and joint pathologic changes were examined in each group after CIA induction. PGE2, IL-1β, IL-6, IL-10, TNF-α, VEGF, MMP-3, IgG and anti-CI...

Artritis Experimental/inducido químicamente, Usos Terapéuticos, Microscopía Electrónica de Transmisión/métodos, Dinoprostona/efectos adversos, Ensayo de Inmunoadsorción Enzimática/métodos, Interleucina-1/farmacología, Interleucina-10/farmacología, Interleucina-6/farmacología, Metaloproteinasas de la Matriz

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IL-10 down-regulates the expression of survival associated gene hspX of Mycobacterium tuberculosis in murine macrophage

Jee, Babban; Sharma, Pawan; Katoch, Kiran; Joshi, Beenu; Awasthi, Sudhir Kumar.

Braz. j. infect. dis; 21 (4), 2017

Abstract Mycobacterium tuberculosis (MTB) adopts a special survival strategy to overcome the killing mechanism(s) of host immune system. Amongst the many known factors, small heat shock protein 16.3 (sHSP16.3) of MTB encoded by gene hspX has been reported to be critical for the survival of MTB. In the pr...

Antígenos Bacterianos/genética, Antígenos Bacterianos/metabolismo, Proteínas Bacterianas/genética, Proteínas Bacterianas/metabolismo, Relación Dosis-Respuesta a Droga, Regulación hacia Abajo/efectos de los fármacos, Regulación Bacteriana de la Expresión Génica/fisiología, Interferón gamma/farmacología, Interleucina-10/farmacología, Macrófagos/microbiología, Mycobacterium tuberculosis/genética, Proteínas Recombinantes/farmacología, Factores de Tiempo

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Effects of IL-10 and glucose on expression of OPG and RANKL in human periodontal ligament fibroblasts

Zhang, L; Ding, Y; Rao, G Z; Miao, D.

Braz. j. med. biol. res; 49 (4), 2016

The effects of interleukin-10 (IL-10) and glucose on mRNA and protein expression of osteoprotegerin (OPG), and its ligand, receptor activator of nuclear factor-κB ligand (RANKL), were investigated in human periodontal ligament fibroblasts (HPDLFs). Primary HPDLFs were treated with different concentr...

Análisis de Varianza, Western Blotting, Células Cultivadas, Regulación hacia Abajo, Fibroblastos/efectos de los fármacos, Fibroblastos/metabolismo, Glucosa/farmacología, Interleucina-10/farmacología, Osteoprotegerina/metabolismo, Ligamento Periodontal/citología, Ligamento Periodontal/efectos de los fármacos, Ligando RANK/metabolismo, ARN Mensajero/análisis, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Factores de Tiempo, Regulación hacia Arriba

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