Abstract Objective: The aim of this study was to evaluate the association between possible functional interleukin-10 (IL-10) polymorphisms, IL-10 expression and regulatory T cells (Tregs) frequency, and/or asthma severity in a sample of children and adolescents. Methods: This is a nested case-control g...
ABSTRACT BACKGROUND: There has been little evidence to suggest that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms are significantly associated with susceptibility to celiac disease. Thus, we performed the present meta-analysis to explore the potential association between these polymorphisms a...
Abstract INTRODUCTION Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background. METHODS We genotyped 298 individuals with HTLV-1 and 380 controls for interleukin-10...
Estudios de Casos y Controles,
Genotipo,
Infecciones por HTLV-I/complicaciones,
Infecciones por HTLV-I/genética,
Virus Linfotrópico T Tipo 1 Humano,
Interleucina-10/genética,
Persona de Mediana Edad,
Fenotipo,
Polimorfismo de Nucleótido Simple/genética,
Vejiga Urinaria Hiperactiva/etiología,
Vejiga Urinaria Hiperactiva/genética
ABSTRACT Introduction: A series of studies have evaluated the association between -592A>C and -819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive. Objective: To better understand the association of the poly...
ABSTRACT BACKGROUND: Several epidemiological studies have investigated the association of promoter region polymorphisms of Interleukin-10 (IL-10) gene with colorectal cancer (CRC), while the conclusion is still conflicting and inconclusive. OBJECTIVE: We conducted this meta-analysis to evaluate the a...
SUMMARY INTRODUCTION The association between the between IL-10 -1082A>G (rs1800896) polymorphism and breast cancer has been evaluated by several number case-control studies. However, these studies might be underpowered to reveal the true association. OBJECTIVE We have performed a comprehensive met...
ABSTRACT BACKGROUND: The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. OBJECTIVE: To clarify the association, we conducted a meta-analysis to inve...
Pueblo Asiatico,
Estudios de Casos y Controles,
Ensayos Clínicos como Asunto,
Población Blanca,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Genotipo,
Hispánicos o Latinos,
Interleucina-10/genética,
Metaanálisis como Asunto,
Polimorfismo Genético/genética,
Regiones Promotoras Genéticas,
Literatura de Revisión como Asunto,
Factores de Riesgo,
Neoplasias Gástricas/etnología,
Neoplasias Gástricas/genética
ABSTRACT Alzheimer's disease (AD) is the most common form of dementia. In the last 15 years, a new theory has proposed the autoimmune mechanism as a trigger for AD. Studies on the association between AD and inflammatory biomarkers have yielded controversial results. Interleukin-10 (IL-10), an anti-inflam...
ABSTRACT Objective This study aimed to investigate the association of plasma TNF-α, IL-6, and lL-10 levels and cytokine gene polymorphisms [TNF-α (-308 G→A), IL-6 (-174 C→G) and IL-10 (-1082 A→G, -819 T→C and -592 A→C)] in type 2 diabetes mellitus (T2DM) and obes...
Biomarcadores/sangre,
Índice de Masa Corporal,
Estudios de Casos y Controles,
Estudios Transversales,
Diabetes Mellitus Tipo 2/sangre,
Diabetes Mellitus Tipo 2/genética,
Frecuencia de los Genes,
Genotipo,
Interleucina-10/sangre,
Interleucina-10/genética,
Interleucina-6/genética,
Obesidad/sangre,
Obesidad/genética,
Reacción en Cadena de la Polimerasa,
Polimorfismo Genético,
Factor de Necrosis Tumoral alfa/sangre,
Factor de Necrosis Tumoral alfa/genética
Abstract Genetic variations observed in cytokines affect periodontitis susceptibility. The aim of this study was to investigate interleukin(IL)-6(-174) and IL-10(-597) gene polymorphisms in generalized aggressive periodontitis (GAgP) patients. Also, we aimed to evaluate the effects of IL-6 and IL-10 gene...
Periodontitis Agresiva/genética,
Periodontitis Agresiva/terapia,
Estudios de Casos y Controles,
Índice de Placa Dental,
Ensayo de Inmunoadsorción Enzimática,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Líquido del Surco Gingival/química,
Interleucina-10/análisis,
Interleucina-10/genética,
Interleucina-6/análisis,
Interleucina-6/genética,
Modelos Logísticos,
Índice Periodontal,
Reacción en Cadena de la Polimerasa,
Polimorfismo de Longitud del Fragmento de Restricción,
Valores de Referencia,
Factores de Tiempo
