LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosus

BACKGROUND: Isodon rugosus is used traditionally in the management of hypertension, rheumatism, tooth-ache and pyrexia. Present study was arranged to investigate I. rugosus for phytoconstituents, phytotoxic and cytotoxic activities to explore its toxicological, pharmacological potentials and to rationali...

Investigations of anticholinestrase and antioxidant potentials of methanolic extract, subsequent fractions, crude saponins and flavonoids isolated from Isodon rugosus

Zeb, Anwar; Sadiq, Abdul; Ullah, Farhat; Ahmad, Sajjad; Ayaz, Muhammad.

Biol. Res; 47 (), 2014

BACKGROUND: Based on the ethnomedicinal uses and the effective outcomes of natural products in various diseases, this study was designed to evaluate Isodon rugosus as possible remedy in oxidative stress, alzheimer's and other neurodegenerative diseases. Acetylecholinestrase (AChE) and butyrylcholinestera...

Antioxidantes/análisis, Inhibidores de la Colinesterasa/análisis, Flavonoides/análisis, Isodon/química, Extractos Vegetales/química, Saponinas/análisis, Acetilcolinesterasa/efectos de los fármacos, Benzotiazoles/metabolismo, Compuestos de Bifenilo/metabolismo, Butirilcolinesterasa/efectos de los fármacos, Flavonoides/aislamiento & purificación, Depuradores de Radicales Libres/metabolismo, Radicales Libres/análisis, Peróxido de Hidrógeno/metabolismo, Isodon/clasificación, Isodon/enzimología, Estrés Oxidativo/efectos de los fármacos, Picratos/metabolismo, Componentes Aéreos de las Plantas/química, Saponinas/aislamiento & purificación, Espectrofotometría/métodos, Ácidos Sulfónicos/metabolismo, Acetatos, Cloroformo, Mezclas Complejas, Hexanos, Concentración 50 Inhibidora, Medicina Tradicional, Metanol

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