SUMMARY: Spinal cord injury (SCI) usually arises from compression due to traffic accidents and falls, resulting in varying degrees of movement, sensory loss, and possible paralysis. Glabridin (Gla) is a natural compound derived from licorice. It significantly affects drug development and medicine because...
Venegas-Casanova, Edmundo;
Gavidia-Valencia, José G;
Curo-Vallejos, Yuri F;
Ríos, Miguel;
Chavez-Abanto, Luis A;
Aro-Díaz, Ruben J;
Escobar, Jorge;
Rubio-López, Felipe Ruben;
Uribe-Villarreal, José;
Martinez, José L;
Rengifo-Penadillos, Roger A.
The conversion factor of nitrogen to proteins and isoflavones present in Glycine max was determined. For the determination of the conversion factor, we worked with solubilizing the proteins at alkaline pH and then extracting them with acidic pH. The proteins were iden...
Purpose: Our aim was to investigate protective effects of daidzein treatment on ischemia-reperfusion (I/R) injury-induced ovarian tissue by immunohistochemical techniques. Methods: Thirty Sprague Dawley female rats were categorized into three groups as sham, I/R group, and I/R+daidzein groups. Bloods we...
O climatério é uma fase natural da vida da mulher que ocorre entre os 40 e 65 anos de idade e é caracterizado pela transição entre a fase reprodutiva e não reprodutiva. Neste período, devido às alterações hormonais, ocorrem alterações biológicas, endócrinas e clínicas. Sintomas vasomotores...
SUMMARY INTRODUCTION Although estrogen therapy is widely used against post-menopausal symptoms, it can present adverse effects, including endometrial cancer. Soy isoflavones are considered a possible alternative to estrogen therapy. However, there are still concerns whether isoflavones exert trophic ef...
Proliferación Celular/efectos de los fármacos,
Cuello del Útero/efectos de los fármacos,
Cuello del Útero/patología,
Epitelio/efectos de los fármacos,
Estrógenos/farmacología,
Inmunohistoquímica,
Isoflavonas/farmacología,
Antígeno Ki-67/análisis,
Membrana Mucosa/efectos de los fármacos,
Ovariectomía,
Fitoestrógenos/farmacología,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Factor A de Crecimiento Endotelial Vascular/análisis
Methylophiopogonanone A (MO-A), a homoisoflavonoid extracted from Ophiopogon japonicus, has been shown to attenuate myocardial apoptosis and improve cerebral ischemia/reperfusion injury. However, the hypolipidemic effects remain unknown. This study was performed to investigate a potential hypolipidemic e...
Benzodioxoles/aislamiento & purificación,
Benzodioxoles/farmacología,
Western Blotting,
Dieta Alta en Grasa,
Modelos Animales de Enfermedad,
Heces/química,
Hiperlipidemias/metabolismo,
Hiperlipidemias/prevención & control,
Isoflavonas/aislamiento & purificación,
Isoflavonas/farmacología,
Metabolismo de los Lípidos,
Lípidos/análisis,
Ophiopogon/química,
Ratas Sprague-Dawley,
Reacción en Cadena en Tiempo Real de la Polimerasa
Hepatocellular carcinoma (HCC) is one of the most common primary malignant tumors of the liver worldwide. Liver resection and transplantation are currently the only effective treatments; however, recurrence and metastasis rates are still high. Previous studies have shown that the epithelial-mesenchymal t...
Antineoplásicos/farmacología,
Antineoplásicos/uso terapéutico,
Carcinoma Hepatocelular/tratamiento farmacológico,
Carcinoma Hepatocelular/genética,
Proliferación Celular/efectos de los fármacos,
Proliferación Celular/genética,
Modelos Animales de Enfermedad,
Ensayos de Selección de Medicamentos Antitumorales,
Transición Epitelial-Mesenquimal/efectos de los fármacos,
Isoflavonas/farmacología,
Isoflavonas/uso terapéutico,
Neoplasias Hepáticas/tratamiento farmacológico,
Neoplasias Hepáticas/genética,
MicroARNs/genética,
Invasividad Neoplásica,
Fosfohidrolasa PTEN/genética,
Pirroles
Despite the development of modern medicine, alternative medicine, which has not lost its timeliness, remains attractive for the treatment of various diseases. Glabridin, a major flavonoid of Glycyrrhiza glabra, is known for its antioxidant and anti-inflammatory activity. The aim of this study was: 1) to...
Isoflavonas/administración & dosificación,
Isoflavonas/farmacología,
Fenoles/administración & dosificación,
Fenoles/farmacología,
Daño por Reperfusión/tratamiento farmacológico,
Íleon/efectos de los fármacos,
Estrés Oxidativo/efectos de los fármacos,
Músculo Liso/efectos de los fármacos,
NG-Nitroarginina Metil Éster,
AMP Cíclico/metabolismo,
GMP Cíclico/metabolismo,
Ratas Wistar,
Malondialdehído/análisis,
AMP Cíclico/análisis,
Íleon/química,
Glycyrrhiza
The consumption of soybean isoflavones (IS) is associated with several beneficial properties on human health. Some lactic acid bacteria possess ß-glucosidase enzyme, that allows to obtain the active form of IS (aglycone). The solid state fermentation (SSF) has received great attention in the last years ...
Fermentación,
Isoflavonas/biosíntesis,
Lacticaseibacillus rhamnosus/metabolismo,
Glycine max/metabolismo,
Productos Vegetales/análisis,
Aminoácidos/metabolismo,
Proteínas Bacterianas/metabolismo,
Microbiología de Alimentos,
Hidrólisis,
Ácido Láctico/biosíntesis,
Sacarosa/farmacología,
beta-Glucosidasa/metabolismo
Abstract This work aimed to evaluate the enzymatic hydrolysis of okara protein concentrate with respect to degree of hydrolysis (DH) in order to obtain a protein hydrolysate with high antioxidant capacity and aglycones isoflavone content. A central composite rotatable design was carried out to evaluate t...
