DNA damage in homocystinuria: 8-oxo-, 8-dihydro-2’-deoxyguanosine levels in cystathionine-β-synthase deficient patients and the in vitro protective effect of N-acetyl‑L‑cysteine
Clin. biomed. res; 38 (1), 2018
Introduction: Homocysteine (Hcy) tissue accumulation occurs in a metabolic disease characterized biochemically by cystathionine β-synthase (CBS) deficiency and clinically by mental retardation, vascular problems, and skeletal abnormalities. Previous studies indicate the occurrence of DNA damage secondar...
Daño del ADN, Homocisteína/sangre, Desoxiguanosina/orina, Homocistinuria/genética, Estrés Oxidativo, Acetilcisteína/farmacología, Antioxidantes/farmacología, Cistationina/metabolismo, Cistationina/biosíntesis, Cistationina/sangre, Desoxiguanosina/análogos & derivados, Isoprostanos/análisis, Creatinina/orina, Biomarcadores/orina, Ensayo Cometa, Estudios de Casos y Controles, Homocistinuria/sangre