Results: 7

Expression of microRNAs miR-126, miR-133b and miR-221 associated with apoptosis in rats submitted to focal cerebral ischemia and physical exercise

Figueiredo, Rafael Zimak; de Assis Cirino, Mucio Luiz; Barbosa Porsani, Lucas; Sanches Lizarte Neto, Fermino; Novais, Paulo Cezar; Nunes, Maria Julia; Lellis, Janaína Regina; da-Silva, Jairo Pinheiro; Tazima, Maria de Fátima Galli Sorita; de Toledo Durand, Marina; Sassoli Fazan, Valeria Paula; Colli, Benedicto Oscar; da Cunha Tirapelli, Daniela Pretti; Tirapelli, Luis Fernando.

Int. j. morphol; 40 (6), 2022

SUMMARY: Stroke is one of the main causes of death and disability worldwide. The great impact on the quality of life of the population and on the health system justifies that we seek relevant alternatives to reduce the incidence and improve the treatment and recovery of patients affected by this disease....

Ejercicio Físico/fisiología, Isquemia Encefálica/genética, MicroARNs/genética, Ratas Wistar, Apoptosis, Reacción en Cadena en Tiempo Real de la Polimerasa, d0154150

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MicroRNA-27b expression in rats submitted to physical exercise and experimental cerebral ischemia

De-Russi, Brenno Marco; Porsani, Lucas Barbosa; Cirino, Mucio Luiz de Assis; Silva, Jairo Pinheiro da; Turra, Letícia Passi; Novais, Paulo Cezar; Lizarte-Neto, Fermino Sanches; Fazan, Valéria de Paula Sassoli; Thomazini, José Antônio; Colli, Benedicto Oscar; Tirapelli, Daniela Pretti da Cunha; Tirapelli, Luis Fernando; Carvalho, Camila Albuquerque Melo de.

Int. j. morphol; 39 (3), 2021

SUMMARY: Cerebral ischemia has not only a high mortality rate, which is the second leading cause of death worldwide, but is also responsible for severe disabilities in working age individuals, generating enormous public expending for treatment and rehabilitation of the affected individuals. The role of m...

Isquemia Encefálica/fisiopatología, Isquemia Encefálica/metabolismo, MicroARNs/metabolismo, Isquemia Encefálica/genética, Ejercicio Físico, Modelos Animales de Enfermedad, Reacción en Cadena en Tiempo Real de la Polimerasa

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Morphometric analysis and pattern of protein and gene expression of apoptosis in focal cerebral ischemia in rats and the neuroprotetive action of hypothermia and ketoprofen

Tirapelli, Daniela P. C; Cirino, Mucio Luiz de Assis; Carvalho, Camila A. Melo de; Novais, Paulo Cezar; Figueredo, Rafael Zimak; Porsani, Lucas Barbosa; Gula, Isabella Stracieri; Rodrigues, Andressa Romualdo; Silva, Jairo Pinheiro da; Pereira, Adriana Lis; Lizarte Neto, Fermino Sanches; Schimming, Bruno Cesar; Tazima, Maria de Fátima Galli Sorita; Fazan, Valéria de Paula Sassoli; Carlotti-Jr, Carlos Gilberto; Tirapelli, Luis Fernando; Colli, Benedicto Oscar.

Int. j. morphol; 38 (3), 2020

This study aimed to investigate the morphometric and the pattern of protein and gene expression related to the extrinsic apoptotic pathway in experimental focal cerebral ischemia and the hole of neuroprotection with hypothermia and ketoprofen. For this analysis, 120 rats were randomly divided into 3 grou...

Isquemia Encefálica/terapia, Isquemia Encefálica/genética, Apoptosis/genética, Hipotermia Inducida, Cetoprofeno/farmacología, Fármacos Neuroprotectores/farmacología, Isquemia Encefálica/patología, Caspasa 8/genética, Caspasa 3/genética, Modelos Animales de Enfermedad, Inmunohistoquímica, Isquemia Encefálica/metabolismo, Reacción en Cadena en Tiempo Real de la Polimerasa

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AIF, PARP-1 and MicroRNA-9 expression in cerebral ischemia associated to alcoholism experimental model

Abrahão, Dayana Pousa Siqueira; Lizarte Neto, Fermino Sanches; Rodrigues, Andressa Romualdo; Cirino, Múcio Luiz de Assis; Silva, Jairo Pinheiro da; Sarraipo, Vagner Schiavoni; Carvalho, Camila Albuquerque Melo de; Tazima, Maria de Fátima Galli Sorita; Carlotti-Jr, Carlos Gilberto; Colli, Benedicto Oscar; Tirapelli, Luís Fernando; Tirapelli, Daniela Pretti da Cunha.

Int. j. morphol; 38 (3), 2020

The chronic consumption of alcohol causes a worsening of the events that follow the cerebral ischemia. These events are regulated through the expression of several genes and microRNAs. The aimof this work was To analyze and describe the expression profile of PARP and AIF and miRNA-9 proteins in rats subm...

Alcoholismo/metabolismo, Alcoholismo/genética, Isquemia Encefálica/metabolismo, Isquemia Encefálica/genética, Modelos Animales de Enfermedad, Factor Inductor de la Apoptosis/metabolismo, Poli(ADP-Ribosa) Polimerasa-1/metabolismo, Inmunohistoquímica, Ratas Wistar, MicroARNs/metabolismo

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Paraoxonase-1 polymorphisms and cerebral ischemic stroke: a pilot study in mexican patients

Martínez-Salazar, María Fernanda; Soriano-Martínez, María de la Luz; Juantorena-Ugas, Alina; Almenares-López, Damianys; Yescas, Petra; Boll, Marie-Catherine; Monroy-Noyola, Antonio.

Colomb. med; 49 (3), 2018

Abstract Background: The serum paraoxonase-1 (PON1) associated to HDL presents two common polymorphisms in the positions 192 and 55. These polymorphisms are considered determinant of the capacity of HDL to protect LDL from their oxidative modification. In this context, the PON1 genotype has been associ...

Arildialquilfosfatasa/genética, Isquemia Encefálica/genética, Predisposición Genética a la Enfermedad, Accidente Cerebrovascular/genética, Alelos, Isquemia Encefálica/patología, Estudios de Casos y Controles, Frecuencia de los Genes, Genotipo, Modelos Lineales, México, Proyectos Piloto, Reacción en Cadena de la Polimerasa, Polimorfismo Genético, Polimorfismo de Longitud del Fragmento de Restricción, Factores de Riesgo, Accidente Cerebrovascular/patología

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Polymorphisms of the lipoprotein lipase gene as genetic markers for stroke in colombian population: a case control study

Velásquez Pereira, Leydi Carolina; Vargas Castellanos, Clara Inés; Silva Sieger, Federico Arturo.

Colomb. med; 47 (4), 2016

Abstract Objective: To analyze if there is an association between the presence of polymorphisms in the LPL gene (rs320, rs285 and rs328) with development of acute ischemic stroke in Colombian population. Methods: In a case control design, 133 acute ischemic stroke patients (clinical diagnosis and x-ra...

Isquemia Encefálica/genética, Marcadores Genéticos, Lipoproteína Lipasa/genética, Accidente Cerebrovascular/genética, Alelos, Estudios de Casos y Controles, Colombia, Genotipo, Reacción en Cadena de la Polimerasa, Polimorfismo Genético, Polimorfismo de Longitud del Fragmento de Restricción

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Antecedentes familiares como factores de riesgo

Familiar antecedents as risk factors

Bergel, Patrick; Saglimbeni, Antonio; García, Rando; Madriz, Simón; Angeli, Germán.

Arch. Hosp. Vargas; 34 (1/2), 1992

En el presente estudio se analizó la tendencia familiar de cinco patologías: hipertensión arterial esencial (HTA), diabetes mellitus (DM), cardiopatía isquémica crónica (CIC), accidentes cerebrovasculares (ACV), y neoplasias malignas (Ca), y la posible relación entre cada una de ellas como factor ...

Diabetes Mellitus/genética, Enfermedad Coronaria/genética, Neoplasias/genética, Hemorragia Cerebral/genética, Isquemia Encefálica/genética