SUMMARY: Stroke is the leading cause of acquired physical disability in adults and second leading cause of mortality throughout the world. Treatment strategies to curb the effects of stroke would be of great benefit. Pongamia pinnata is a recent attraction in medicine, owing to its abundant medicinal ben...
Millettia/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Accidente Cerebrovascular/tratamiento farmacológico,
Ratas Wistar,
Modelos Animales de Enfermedad,
Corteza Cerebral/efectos de los fármacos,
Isquemia Encefálica/tratamiento farmacológico,
Factor Neurotrófico Derivado del Encéfalo/genética,
Factor Neurotrófico Derivado de la Línea Celular Glial/genética,
Factor 1 Inducible por Hipoxia/genética,
FN-kappa B,
Administración Oral,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factores de Crecimiento Nervioso/administración & dosificación
Resumen La fibrinólisis intravenosa con activador del plasminógeno tisular recombinante (rTPA) y la utilización de unidades cerradas, demostraron disminuir sustancialmente la morbimortalidad en pacientes con accidente cerebrovascular isquémico (ACVi). Sin embargo, los datos publicados en Argentina so...
We report a 78-year-old man with a basal Rankin score of 2 points, last seen 10 hours before in good conditions, who arrived at the emergency department with left hemiparesis, hypoesthesia, and spacial neglect. Neuroimaging was compatible with stroke in the territory of the right middle cerebral artery. ...
OBJECTIVES: To investigate the safety and efficacy of combined tirofiban-ozagrel therapy for treating progressive stroke patients out of thrombolytic therapy time window. METHODS: This prospective, double-blind, randomized controlled study included 337 patients who had experienced an acute ischemic stro...
It is known that neuronal apoptosis contributes to pathology of cerebral ischemia injury. Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies. The present study investigated whether the anti-apoptotic effect can account for the neuroprotective action of ZNS on cerebral ischemia. Neuronal ...
This study aimed to explore the effect of intravenous thrombolysis with alteplase on clinical efficacy, inflammatory factors, and neurological function in patients with acute cerebral infarction. A total of 120 patients with acute cerebral infarction were divided into two groups by the random number tabl...
Abstract Background: Low-dose alteplase (LrtPA) has been shown not to be inferior to the standard-dose (SrtPA) with respect to death/disability. Objective: We aim to evaluate the percentage of patients treated with LrtPA at our center after the ENCHANTED trial and the factors associated with the use of...
ABSTRACT Background: Statin therapy has become one of the most important advances in stroke secondary prevention. Objective: To provide evidence from real-world data for evaluating detailed associations between secondary prevention of stroke and statin use in Brazil. Methods: We conducted a prospec...
Brunser, Alejandro M.;
Mazzon, Enrico;
Muñoz, Paula;
Hoppe, Arnold;
Lavados, Pablo M.;
Rojo, Alexis;
Navia, Víctor;
Cavada, Gabriel;
Olavarría, Verónica V.;
Mansilla, Eloy.
Background: Intravenous thrombolysis (IT) in acute ischemic stroke (AIS) is time dependent. The time elapsed from hospital admission to the thrombolytic bolus is named door to needle time (DNT) and is recommend to be of less than 60 min. Aim: To describe the DNT in our center and determine those factors ...
Furlan, Natalia Eduarda;
Souza, Juli Thomaz de;
Bazan, Silméia Garcia Zanati;
Franco, Roberto Jorge da Silva;
Luvizutto, Gustavo José;
Gut, Ana Lúcia;
Modolo, Gabriel Pinheiro;
Winckler, Fernanda Cristina;
Martin, Luis Cuadrado;
Bazan, Rodrigo.
Abstract Ischemic stroke is a common cause of death. The role of statins in the secondary prevention of the chronic ischemic stroke phase has been established. However, evidence regarding their efficacy in this phase is limited and contradictory. Objective: To evaluate the association between statin us...
