CXCL8(3-72) K11R/G31P protects against sepsis-induced acute kidney injury via NF-κB and JAK2/STAT3 pathway
Biol. Res; 52 (), 2019
BACKGROUND: Acute kidney injury (AKI), which is mainly caused by sepsis, has high morbidity and mortality rates. CXCL8(3-72) K11R/G31P (G31P) can exert therapeutic effect on inflammatory diseases and malignancies. We aimed to investigate the effect and mechanism of G31P on septic AKI. METHODS: An AKI mou...
Lesión Renal Aguda/etiología, Janus Quinasa 2/metabolismo, FN-kappa B/metabolismo, Factor de Transcripción STAT3/metabolismo, Sepsis/complicaciones, Lesión Renal Aguda/metabolismo, Lesión Renal Aguda/patología, Sepsis/patología, Apoptosis, Modelos Animales de Enfermedad, Ratones Endogámicos C57BL, Transducción de Señal