LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Treatment with Raloxifene Induces the Expression of Kisspeptin, Insulin, and Androgen Receptors in Bones of Castrated Adult Female Rats

Condi, Fernanda Lopes de Freitas; Fuchs, Luiz Fernando Portugal; Carvalho, Katia Candido; Baracat, Edmund Chada.

Rev. Bras. Ortop. (Online); 59 (2), 2024

Abstract Objective To evaluate the effects of estrogen, raloxifene and genistein on the expression of KISS1 (kisspeptin), KISS1R (kisspeptin receptor), AR (androgen receptor) and INSR (insulin receptor) in the bones of ovariectomized rats. Methods Forty-eight adult rats were randomly divided into 6 gro...

Clorhidrato de Raloxifeno/uso terapéutico, Estrógenos, Genisteína, Kisspeptinas, Osteoporosis

Fulltext

Pioneering studies on monogenic central precocious puberty

Canton, Ana Pinheiro Machado; Seraphim, Carlos Eduardo; Brito, Vinicius Nahime; Latronico, Ana Claudia.

Arch. endocrinol. metab. (Online); 63 (4), 2019

ABSTRACT Pubertal timing in humans is determined by complex interactions including hormonal, metabolic, environmental, ethnic, and genetic factors. Central precocious puberty (CPP) is defined as the premature reactivation of the hypothalamic-pituitary-gonadal axis, starting before the ages of 8 and 9 yea...

Proteínas de Unión al Calcio, Silenciador del Gen, Péptidos y Proteínas de Señalización Intercelular/genética, Péptidos y Proteínas de Señalización Intercelular/metabolismo, Kisspeptinas/genética, Proteínas de la Membrana/genética, Proteínas de la Membrana/metabolismo, Metilación, Mutación, Fenotipo, Pubertad Precoz/etiología, Pubertad Precoz/genética, Receptores de Kisspeptina-1/genética, Ribonucleoproteínas/genética

Fulltext

Interactions between prolactin and kisspeptin to control reproduction

Donato Jr, Jose; Frazão, Renata.

Arch. endocrinol. metab. (Online); 60 (6), 2016

ABSTRACT Prolactin is best known for its effects of stimulating mammary gland development and lactogenesis. However, prolactin is a pleiotropic hormone that is able to affect several physiological functions, including fertility. Prolactin receptors (PRLRs) are widely expressed in several tissues, includi...

Hiperprolactinemia/complicaciones, Hipotálamo/metabolismo, Infertilidad/etiología, Kisspeptinas/metabolismo, Prolactina/metabolismo, Prolactina/farmacología, Receptores de Prolactina/metabolismo, Reproducción/fisiología, Factores Sexuales, Transducción de Señal

Fulltext