LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Hypericum perforatum chronic treatment affects cognitive parameters and brain neurotrophic factor levels

Valvassori, Samira S; Borges, Cenita; Bavaresco, Daniela V; Varela, Roger B; Resende, Wilson R; Peterle, Bruna R; Arent, Camila; Budni, Josiane; Quevedo, João.

Braz. J. Psychiatry (São Paulo, 1999, Impr.); 40 (4), 2018

Objective: To evaluate the effects of Hypericum perforatum (hypericum) on cognitive behavior and neurotrophic factor levels in the brain of male and female rats. Methods: Male and female Wistar rats were treated with hypericum or water during 28 days by gavage. The animals were then subjected to the ope...

Cognición/efectos de los fármacos, Relación Dosis-Respuesta a Droga, Lóbulo Frontal/efectos de los fármacos, Lóbulo Frontal/metabolismo, Hipocampo/efectos de los fármacos, Hipocampo/metabolismo, Hypericum, Locomoción/efectos de los fármacos, Memoria/efectos de los fármacos, Modelos Animales, Factores de Crecimiento Nervioso/análisis, Factores de Crecimiento Nervioso/efectos de los fármacos, Patrones de Reconocimiento Fisiológico/efectos de los fármacos, Extractos Vegetales/administración & dosificación, Extractos Vegetales/farmacología, Distribución Aleatoria, Ratas Wistar, Factores Sexuales, Resultado del Tratamiento

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A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats

BACKGROUND: It has been proposed that the γ-aminobutyric acid (GABA) plays a key role in the regulation of food intake and body weight by controlling the excitability, plasticity and the synchronization of neuronal activity in the frontal cortex (FC). It has been also proposed that the high-fat diet (HF...