BACKGROUND Cannabinoid compounds have been approved as prescription drugs for treating various human ailments. However, the production using both microbial and plant-based sources is timeconsuming and expensive because their yield is extremely low. Tetraketide synthase (TKS), the key enzyme in the biosyn...
ABSTRACT Purpose: To evaluate the influence of atractylenolide (Atr) III on sepsis-induced lung damage. Methods: We constructed a mouse sepsis model through cecal ligation and puncture. These mice were allocated to the normal, sepsis, sepsis + Atr III-L (2 mg/kg), as well as Atr III-H (8 mg/kg) group. ...
Abstract Nanoparticles demonstrate an important role in the protection of bioactive compounds from external factors such as temperature, oxygen and light. In this study, poly-ε-caprolactone (PCL) nanoparticles entrapped β-carotene was produced using the nanoprecipitation method. Firstly, was ev...
Abstract Yacon is a tuberous root from the Andean region being increasingly grown across the world due to the low caloric values of their roots and the functional properties of extractions of its leaves. However, there is still a gap in the knowledge of how the plant develops, and if physical and chemica...
Menezes-Rodrigues, Francisco Sandro;
Errante, Paolo Ruggero;
Ferreira, Regiane Miranda;
Tavares, José Gustavo Padrão;
Paula, Luciana de;
Araújo, Erisvaldo Amarante;
Govato, Tânia Carmem Peñaranda;
Tikazawa, Eduardo Hiroshi;
Reis, Maria do Carmo Maia;
Luna-Filho, Bráulio;
FerrazI, Renato Ribeiro Nogueira;
Souza Oliveira-Júnior, Itamar de;
Taha, Murched Omar;
Caricati-Neto, Afonso.
Abstract Purpose: To evaluate in vivo animal model of cardiac ischemia/reperfusion the cardioprotective activity of pancreatic lipase inhibitor of the orlistat. Methods: Adult male Wistar rats were anesthetized, placed on mechanical ventilation and underwent surgery to induce cardiac I/R by obstructin...
Arritmias Cardíacas/prevención & control,
Bloqueo Atrioventricular/prevención & control,
Cardiotónicos/farmacología,
Creatina Quinasa/sangre,
Electrocardiografía,
L-Lactato Deshidrogenasa/sangre,
Lactonas/farmacología,
Lipoproteínas HDL/sangre,
Lipoproteínas LDL/sangre,
Lipoproteínas VLDL/sangre,
Infarto del Miocardio/sangre,
Infarto del Miocardio/prevención & control,
Daño por Reperfusión Miocárdica/sangre,
Daño por Reperfusión Miocárdica/prevención & control,
Orlistat,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Riesgo,
Resultado del Tratamiento,
Triglicéridos/sangre
Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses prostaglandins to evade innate barriers, thus enabling the parasites to survive inside immune cells. Despite the role of the enzyme Phospholipase A2 (PLA2) in prostaglandins ...
Abstract Considering oral diseases, antibiofilm compounds can decrease the accumulation of pathogenic species such as Streptococcus mutans at micro-areas of teeth, dental restorations or implant-supported prostheses. Objective To assess the effect of thirteen different novel lactam-based compounds on th...
Análisis de Varianza,
Antibacterianos/síntesis química,
Antibacterianos/farmacología,
Biopelículas/efectos de los fármacos,
Biopelículas/crecimiento & desarrollo,
Recuento de Colonia Microbiana,
Relación Dosis-Respuesta a Droga,
Violeta de Genciana,
Lactonas/síntesis química,
Lactonas/farmacología,
Pruebas de Sensibilidad Microbiana,
Viabilidad Microbiana/efectos de los fármacos,
Microscopía Electrónica de Rastreo,
Plancton/efectos de los fármacos,
Plancton/crecimiento & desarrollo,
Reproducibilidad de los Resultados,
Streptococcus mutans/efectos de los fármacos,
Streptococcus mutans/crecimiento & desarrollo,
Resistencia betalactámica/efectos de los fármacos,
beta-Lactamas/síntesis química,
beta-Lactamas/farmacología
Squamocin belongs to a group of compounds called annonaceous acetogenins. They are secondary products of Annonaceae metabolism and can be isolated from Annona cherimolia seeds. This paper deals with the stimulation of biofilm formation of Bacillus atrophaeus CN4 by employing low squamocin concentrations ...
Picinin, L. C. A;
Toaldo, I. M;
Hoff, R. B;
Souza, F. N;
Leite, M. O;
Fonseca, L. M;
Diniz, S. A;
Silva, M. X;
Haddad, J. P. A;
Cerqueira, M. M. O. P;
Bordignon-Luiz, M. T.
The present study aimed to identify the climate condition parameters that are associated with the occurrence of antimicrobial and macrocyclic lactone residues in bulk tank milk using a multivariate principal components analysis (PCA). A total of 132 raw milk samples were collected at dairy farms in Minas...
ABSTRACT A new lactone, 7-epi-griffonilide (1), and six known compounds, 2, 3a - 3c, 4a and 4b, were isolated from the leaves of Bauhinia pentandra (Fabaceae). The structures elucidation of 1 and 2 were based on detailed 2D NMR techniques and spectral comparison with related compounds, leading to complet...
