LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

Oliveira, Saulo Gomes de; Souza, Ilana Brito Ferraz de; Constantino, Taynan da Silva; Silva, Paula Carolina Valença; Lima, Elker Lene Santos de; Muniz, Maria Tereza Cartaxo; Domingues, Ana Lúcia Coutinho.

Rev. Soc. Bras. Med. Trop; 54 (), 2021

Abstract INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involvin...

Brasil, Exones/genética, Predisposición Genética a la Enfermedad, Genotipo, Cirrosis Hepática/genética, Lectina de Unión a Manosa/genética, Polimorfismo Genético, Polimorfismo de Nucleótido Simple, Estudios Retrospectivos, Esquistosomiasis/genética

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Mannose-binding lectin gene polymorphism and its effect on short term outcomes in preterm infants

Abstract Objective: Mannose-binding lectin, which belongs to the collectin family, is an acute-phase reactant that activates the complement system. This study aimed to investigate the effect of MBL2 gene polymorphism on short-term outcomes in preterm infants. Method: Infants of <37 gestational weeks...