As leishmanioses são doenças negligenciadas que afetam mais de um bilhão e meio de pessoas ao redor do mundo, principalmente nos países em desenvolvimento, provocando grandes impactos socioeconômicos. Os fármacos disponíveis para o tratamento dessas doenças são ineficazes e apresentam graves efe...
Os produtos naturais são uma importante fonte de moléculas com aplicações terapêuticas e biotecnológicas. No entanto, a complexidade inerente às matrizes biológicas e as crescentes taxas de redescoberta de moléculas impõem desafios para a busca por novos compostos bioativos. A exploração de n...
Andrade, João Paulo Campos;
Alves, Osvaine Junior Alvarenga;
Costa, Marian Caroline;
Gimenez, Valéria Maria Melleiro;
Squarisi, Iara Silva;
Nicolella, Heloiza Diniz;
Pagotti, Mariana Cintra;
Tavares, Denise Crispim;
Cunha, Wilson Roberto;
Silva, Márcio Luís Andrade e;
Januario, Ana Helena;
Magalhães, Lizandra Guidi;
Pauletti, Patrícia Mendonça.
Abstract Adenocalymma axillarum (K.Schum.) L.G. Lohmann is a liana belonging to the family Bignoniaceae. In traditional medicine, the genus Adenocalymma is used to treat fever, skin ailments, and body, joint, and facial muscle pains, and it is also applied as cosmetic. Biological assays conducted with th...
In the present study a series of 34 synthetic ligustrazine-containing α, β-Unsaturated carbonyl-based compounds and oximes, recognized as anticancer compounds were assessed against protozoa of the Trypanosoma and Leishmania species. Ligustrazine, chemically known as tetramethylpyrazine (TMP), was selec...
Despite some phlebotomines being well recognised as vectors of leishmaniasis agents, vector importance of those belonging to the genus Trichophoromyia has not been extensively studied. The present study provides evidence regarding the putative vector role played by some species of Trichophoromyia on leis...
Abstract Leishmaniases are a group of diseases of zoonotic importance caused by over 20 species of protozoa of the genus Leishmania, in which domestic dogs are considered to be the main reservoir for the disease. However, the involvement of other vertebrates as reservoirs for these parasites has also bee...
Abstract Introduction: The study of the interaction between the parasite, the vector and the mammalian hosts, including man, allows to understand the behavior of the leishmaniases. Objective: To determine the presence of Lutzomyia species and to detect the Leishmania infection in Didelphis marsupialis ...
Didelphis,
Reservorios de Enfermedades/parasitología,
Insectos Vectores,
Leishmaniasis Visceral/epidemiología,
Psychodidae,
Sangre/parasitología,
Colombia/epidemiología,
Didelphis/parasitología,
Oído Externo/parasitología,
Enfermedades Endémicas,
Proteínas HSP70 de Choque Térmico/genética,
Vivienda,
Insectos Vectores/parasitología,
Leishmania/clasificación,
Leishmania/genética,
Leishmania/aislamiento & purificación,
Leishmaniasis Visceral/transmisión,
Psychodidae/parasitología,
Población Rural,
Especificidad de la Especie,
Cola (estructura animal)/parasitología
Abstract Introduction: Knowledge of the geographical distribution of Leishmania species allows guiding the sampling to little-studied areas and implementing strategies to define risk zones and priority areas for control. Objective: Given that there is no publication that collects this information, the ...
Leishmania,
Colombia,
Reservorios de Enfermedades/parasitología,
Geografía Médica,
Insectos Vectores/parasitología,
Leishmania/clasificación,
Leishmaniasis/epidemiología,
Leishmaniasis/parasitología,
Leishmaniasis/veterinaria,
Mamíferos/parasitología,
Parasitología/Métodos,
Psychodidae/parasitología,
Especificidad de la Especie
Abstract INTRODUCTION: Leishmania species cause skin, mucosal, and disseminated lesions. We studied the effects of three Leishmania species on ileal morphology in mice. METHODS: BALB/c mice were intraperitoneally inoculated with Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, a...
This study aimed to verify the occurrence of Leishmania spp. and Leishmania (Leishmania) infantum in horses from a visceral leishmaniasis endemic area in Brazil. DNA samples from blood and conjunctival swab (CS) were tested by PCR and Indirect Immunofluorescence Antibody Test (IFAT). Although none of the...
