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Leishmania infantum induces high phagocytic capacity and intracellular nitric oxide production by human proinflammatory monocyte

Ribeiro, Christiana Vargas; Rocha, Bruna Fonte Boa; Oliveira, Edward; Teixeira-Carvalho, Andrea; Martins-Filho, Olindo Assis; Murta, Silvane Maria Fonseca; Peruhype-Magalhães, Vanessa.
Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND The mechanism of resistance to SbIII in Leishmania is complex, multifactorial and involves not only biochemical mechanisms, but also other elements, such as the immune system of the host. OBJECTIVES In this study, putative changes in the immunological profile of human monocytes infected wit...
Antimonio/farmacología, Antiprotozoarios/farmacología, Resistencia a Medicamentos, Citometría de Flujo, Inmunidad Innata, Leishmania braziliensis/efectos de los fármacos, Leishmania braziliensis/inmunología, Leishmania infantum/efectos de los fármacos, Leishmania infantum/inmunología, Monocitos/inmunología, Monocitos/parasitología, Óxido Nítrico/biosíntesis, Fagocitosis/inmunología
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Serological study of feline leishmaniasis and molecular detection of Leishmania infantum and Leishmania braziliensis in cats (Felis catus)

Costa-Val, Adriane Pimenta da; Coura, Fernanda Morcatti; Barbieri, Jonata de Melo; Diniz, Luiza; Sampaio, Agnes; Reis, Jenner Karlisson Pimenta dos; Bueno, Bruna Lopes; Gontijo, Célia Maria Ferreira.
Rev. bras. parasitol. vet; 29 (2), 2020
Abstract Blood samples and swabs from ocular conjunctiva and mouth were obtained from 64 cats. Of 64 serum samples, 19 were positive for Leishmania antibodies by ELISA (29.80%). Eight cats were positive by PCR (12.5%) in swab samples from mouth and/or ocular mucosa. Poor kappa agreement between serologic...
Anticuerpos Antiprotozoarios/sangre, Enfermedades de los Gatos/diagnóstico, Enfermedades de los Gatos/parasitología, ADN Protozoario/análisis, Ensayo de Inmunoadsorción Enzimática/veterinaria, Leishmania braziliensis/genética, Leishmania braziliensis/inmunología, Leishmania braziliensis/aislamiento & purificación, Leishmania infantum/genética, Leishmania infantum/inmunología, Leishmania infantum/aislamiento & purificación, Leishmaniasis/diagnóstico, Leishmaniasis/parasitología, Filogenia, Reacción en Cadena de la Polimerasa/veterinaria
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New strategy to improve quality control of Montenegro skin test at the production level

Guedes, Deborah Carbonera; Minozzo, João Carlos; Pasquali, Aline Kuhn Sbruzzi; Faulds, Craig; Soccol, Carlos Ricardo; Thomaz-Soccol, Vanete.
Rev. Soc. Bras. Med. Trop; 50 (6), 2017
Abstract INTRODUCTION: The production of the Montenegro antigen for skin test poses difficulties regarding quality control. Here, we propose that certain animal models reproducing a similar immune response to humans may be used in the quality control of Montenegro antigen production. METHODS: Fifteen C...
Antígenos de Protozoos/biosíntesis, Antígenos de Protozoos/inmunología, Pruebas Intradérmicas/normas, Leishmania/inmunología, Leishmania braziliensis/inmunología, Leishmaniasis Cutánea/diagnóstico, Modelos Animales, Valor Predictivo de las Pruebas, Control de Calidad, Sensibilidad y Especificidad
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Identification and purification of a 72kDa antigen of Leishmania braziliensis braziliensis present on the surface and in the cytoplasm of the promastigotes and its specific recognition by sera from mucocutaneous leishmaniasis patients

Kutner, S; Pellerin, P; Brenière, S. F; Desjeux, P; Dedet, J. P.
Mem. Inst. Oswaldo Cruz; 83 (supl.1), 1988
Leishmaniasis Mucocutánea/inmunología, Leishmaniasis Mucocutánea/sangre, Leishmania braziliensis/inmunología, Glicoproteínas, Antígenos de Superficie, Antígenos de Protozoos, Reacciones Antígeno-Anticuerpo
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Leishmaniose tegumentar americana: imunopatologia diagnóstica e contribuiçäo à patogenia

Sotto, Mírian Nacagami.
O quadro histopatológico da Leishmaniose Tegumentar Americana (LTA) é representaod por inflamaçäo crônica inespecífica por vezes com formaçäo de granulomas epitelióides. A plasmocitose, as alteraçöes do colágeno e vasculares associadas completam o quadro sugestivo, porém näo característico...
Leishmaniasis Cutánea/patología, Leishmania braziliensis/inmunología, Leishmania mexicana/inmunología, Biopsia