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Evaluation of different total Leishmania amazonensis antigens for the development of a first-generation vaccine formulated with a Toll-like receptor-3 agonist to prevent cutaneous leishmaniasis

Germanó, María José; Lozano, Esteban Sebastián; Sanchez, María Victoria; Bruna, Flavia Alejandra; García-Bustos, María Fernanda; Sosa Lochedino, Arianna Lourdes; Salomón, María Cristina; Fernandes, Ana Paula; Mackern-Oberti, Juan Pablo; Cargnelutti, Diego Esteban.
Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND Unfortunately, no any vaccine against leishmaniasis has been developed for human use. Therefore, a vaccine based on total Leishmania antigens could be a good and economic approach; and there are different methodologies to obtain these antigens. However, it is unknown whether the method to obt...
Antígenos de Protozoos/inmunología, Leishmania, Vacunas contra la Leishmaniasis, Leishmaniasis Cutánea/inmunología, Leishmaniasis Cutánea/prevención & control, Ratones Endogámicos BALB C, Vacunas Antiprotozoos/inmunología, Receptor Toll-Like 3/inmunología
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Disseminated leishmaniasis: clinical, pathogenic, and therapeutic aspects

Machado, Gustavo Uzêda; Prates, Fernanda Ventin; Machado, Paulo Roberto Lima.
An. bras. dermatol; 94 (1), 2019
Abstract: Disseminated leishmaniasis is a severe and emerging form of American tegumentary leishmaniasis. Disseminated leishmaniasis is defined by the presence of more than 10 polymorphic cutaneous lesions, distributed over more than two noncontiguous parts of the body. Nasal mucosal involvement is obser...
Anfotericina B/uso terapéutico, Antiprotozoarios/uso terapéutico, Leishmania braziliensis, Leishmaniasis Cutánea/tratamiento farmacológico, Leishmaniasis Cutánea/inmunología, Leishmaniasis Cutánea/patología, Resultado del Tratamiento
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Clinico-immunological spectrum of American tegumentary leishmaniasis and leprosy coinfection: A case series in Southeastern Brazil

Vernal, Sebastian; Bueno-Filho, Roberto; Gomes, Ciro Martins; Roselino, Ana Maria.
Rev. Soc. Bras. Med. Trop; 52 (), 2019
Abstract INTRODUCTION: American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce. METHODS: We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of c...
Coinfección/inmunología, Leishmaniasis Cutánea/complicaciones, Leishmaniasis Cutánea/inmunología, Lepra/complicaciones, Lepra/inmunología, Persona de Mediana Edad, Células TH1/inmunología, Células Th2/inmunología
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Cytotoxic activity in cutaneous leishmaniasis

Campos, Taís M; Costa, Rúbia; Passos, Sara; Carvalho, Lucas P.
Mem. Inst. Oswaldo Cruz; 112 (11), 2017
Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammat...
Linfocitos T CD8-positivos/inmunología, Linfocitos T CD8-positivos/parasitología, Citotoxicidad Inmunológica/inmunología, Modelos Animales de Enfermedad, Células Asesinas Naturales/efectos de los fármacos, Células Asesinas Naturales/parasitología, Leishmaniasis Cutánea/inmunología, Leishmaniasis Cutánea/patología, Linfocitos T Citotóxicos/inmunología
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