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Analysis of macrophage subtypes and annexin A1 expression in lesions of patients with cutaneous leishmaniasis

Silva, Joselina Maria da; Silva, Helen Aguiar Lemes da; Zelenski, Carolina; Souza, Jéssica Azevedo de Moraes; Hueb, Marcia; Damazo, Amílcar Sabino.
Rev. Soc. Bras. Med. Trop; 52 (), 2019
Abstract INTRODUCTION: Cutaneous leishmaniasis is caused by protozoa of the genus Leishmania and transmission occurs through the bite of sandflies. It is an infectious disease, which affects skin and mucosa. The aim was to quantify the macrophages M1 and M2 and the annexin A1 expression in the skin les...
Anexina A1/análisis, Anexina A1/metabolismo, Biopsia, Técnica del Anticuerpo Fluorescente, Leishmaniasis Cutánea/metabolismo, Leishmaniasis Cutánea/patología, Macrófagos/metabolismo, Macrófagos/parasitología, Persona de Mediana Edad, Reacción en Cadena de la Polimerasa, Polimorfismo de Longitud del Fragmento de Restricción
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N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis

Gasparotto, Juciano; Kunzler, Alice; Senger, Mario Roberto; Souza, Celeste da Silva Freitas de; Simone, Salvatore Giovanni de; Bortolin, Rafael Calixto; Somensi, Nauana; Dal-Pizzol, Felipe; Moreira, José Claudio Fonseca; Abreu-Silva, Ana Lúcia; Calabrese, Kátia da Silva; Silva Jr, Floriano Paes; Gelain, Daniel Pens.
Mem. Inst. Oswaldo Cruz; 112 (2), 2017
BACKGROUND Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. a...
Acetilcisteína/farmacología, Depuradores de Radicales Libres/farmacología, Leishmania mexicana, Leishmaniasis Cutánea/metabolismo, Leishmaniasis Cutánea/patología, Hígado/efectos de los fármacos, Hígado/enzimología, Ratones Endogámicos BALB C, Estrés Oxidativo/efectos de los fármacos, Estrés Oxidativo/fisiología
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