Results: 12

Avaliação do perfil de citocinas séricas e óxido nítrico na hanseníase experimental murina

Hansen. int; 49 (), 2024
Introdução: a hanseníase é uma do-ença infecciosa crônica causada pelo Mycobacterium leprae (M. leprae), um para-sita intracelular obrigatório. Assim, a resis-tência do hospedeiro a esse patógeno depen-de da imunidade celular. O uso de modelos experimentais tem permitido...

Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae

Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host inflammatory and immune responses. More recently, the inflamma...

Leprosy: prevalence and factors associated with seropositivity for anti-NDO-LID antibodies in children under 15 years of age

An. bras. dermatol; 94 (4), 2019
Abstract: Background: A high prevalence of leprosy among children under 15 years of age indicates the need to implement actions to prevent new cases of the disease. Serological tests have been developed with the aim of helping to control the disease by indicating, through seropositivity, the presence of...

Clinico-immunological spectrum of American tegumentary leishmaniasis and leprosy coinfection: A case series in Southeastern Brazil

Abstract INTRODUCTION: American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce. METHODS: We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of c...

Polymorphisms in genes TLR1, 2 and 4 are associated with differential cytokine and chemokine serum production in patients with leprosy

Mem. Inst. Oswaldo Cruz; 112 (4), 2017
BACKGROUND Leprosy or hansen’s disease is a spectral disease whose clinical forms mostly depends on host’s immune and genetic factors. Different Toll-like receptors (TLR) variants have been described associated with leprosy, but with some lack of replication across different populations. OB...

Possible mechanisms of chronic leprosy-related arthritis

Säo Paulo med. j; 115 (2), 1997
Microbial agents induce arthritis through mechanisms such as direct infiltration of tissue and by inducing autoimmune phenomena. The mechanisms involved in this last type of arthritis have been investigated. In experimental models of adjuvant and reactive arthritis, the involvement of T cells and in some...

Estudio de la lepra en el policlínico "Emilio Daudinot"
Study of leprosy at \"Emilio Daudinot\" polyclinics

Rev. cuba. enferm; 9 (2), 1993
Se realiza un estudio de la prevalencia de lepra en el policlínico "Emilio Daudinot" del minucipio Guantánamo. Se da a conocer el comportamiento de la lepra según las formas clínicas, y da como resultado que la forma lepromatosa es la más frecuente, así como el número de pacientes baciloscópicame...

Vacunas para la lepra
Vaccines for leprosy

La lepra, enfermedad de Hansen o hanseniasis, es una enfermedad infecciosa crónica del hombre causada por Mycobacterium leprae; afecta a los nervios periféricos, la piel y la mucosa de las vías respiratorias superiores y secundariamente a ojos, huesos, músculos y testículos. La premisa mayor para el...

Estudio de anticuerpos antimicobacterianos en enfermos de lepra y contactos
Antimycobacterial antibodies in patients with leprosy and contacts

El trabajo hace énfasis en líneas de investigación que podrían tener un impacto práctico sobre las medidas de control en um futuro no muy lejano. Se presta especial atención a los estudios de anticuerpos antimicobacterianos para detectar la infección subclínica y evaluar la actividad clínica, re...