LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Clinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): adverse effects approach

Cruz, Rossilene Conceição da Silva; Bührer-Sékula, Samira; Penna, Gerson Oliveira; Moraes, Maria Elisabete Amaral de; Gonçalves, Heitor de Sá; Stefani, Mariane Martins de Araújo; Penna, Maria Lúcia Fernandes; Pontes, Maria Araci de Andrade; Talhari, Sinésio.

An. bras. dermatol; 93 (3), 2018

Abstract: BACKGROUND: The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR), designed to evaluate the effectiveness of a six-months regimen, assessed the adverse effects caused by the drugs. OBJECTIVE: Describe adverse effects due to MDT in U-MDT/CT-BR, comparing...

Anemia/sangre, Anemia/inducido químicamente, Brasil, Clofazimina/administración & dosificación, Clofazimina/efectos adversos, Dapsona/administración & dosificación, Dapsona/efectos adversos, Quimioterapia Combinada/efectos adversos, Hemoglobinas/análisis, Leprostáticos/administración & dosificación, Leprostáticos/efectos adversos, Lepra/sangre, Lepra/complicaciones, Lepra/tratamiento farmacológico, Rifampin/administración & dosificación, Rifampin/efectos adversos, Factores de Riesgo, Resultado del Tratamiento

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Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts

BACKGROUND There is a lack of straightforward tests for field application and known biomarkers for predicting leprosy progression in infected individuals. OBJECTIVE The aim was to analyse the response to infection by Mycobacterium leprae based on the reactivity of specific antigens: natural disacchari...