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Modeling Mediated Crossover Acute and Subacute Damage to the Pulmonary System During Systemic (Subcutaneous) Administration of Bleomycin in Mice to Test the Potential Therapeutic Effect of Polyphenols

Shulgau, Zarina; Kamyshanskiy, Yevgeniy; Sergazy, Shynggys; Zhulikeyeva, Aigerim; Urazbayeva, Assel; Makhmutova, Ainura; Bokebayev, Zhanybek; Gulyayev, Alexandre; Ramankulov, Yerlan.
Int. j. morphol; 41 (6), 2023
SUMMARY: The potential anti-inflammatory and antifibrotic activity of polyphenolic extracts of blueberry and grape was evaluated in a mouse model of lung damage induced by subcutaneous administration of bleomycin. The results of testing the polyphenolic extracts on two different systemic administration v...
Bleomicina/toxicidad, Lesión Pulmonar/inducido químicamente, Lesión Pulmonar/tratamiento farmacológico, Lesión Pulmonar/patología, Pulmón/efectos de los fármacos, Polifenoles/administración & dosificación, Extractos Vegetales/administración & dosificación, Antiinflamatorios/administración & dosificación, Modelos Animales de Enfermedad, Arándanos Azules (Planta)/química, Vitis/química
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Local and systemic effects of fibrin and cyanoacrylate adhesives on lung lesions in rabbits

Carvalho, Marcus VH; Marchi, Evaldo; Fruchi, Andre J; Dias, Bruno VB; Pinto, Clovis L; dos Santos, Geovane R; Acencio, Milena MP.
Clinics; 72 (10), 2017
OBJECTIVES: Tissue adhesives can be used to prevent pulmonary air leaks, which frequently occur after lung interventions. The objective of this study is to evaluate local and systemic effects of fibrin and cyanoacrylate tissue adhesives on lung lesions in rabbits. METHODS: Eighteen rabbits were submitte...
Cianoacrilatos/uso terapéutico, Ensayo de Inmunoadsorción Enzimática, Adhesivo de Tejido de Fibrina/uso terapéutico, Hemodinámica, Interleucina-8/sangre, Recuento de Leucocitos, Pulmón/efectos de los fármacos, Pulmón/patología, Lesión Pulmonar/tratamiento farmacológico, Distribución Aleatoria, Valores de Referencia, Reproducibilidad de los Resultados, Toracoscopía/métodos, Factores de Tiempo, Adhesivos Tisulares/uso terapéutico, Resultado del Tratamiento
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