LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Glycogen synthase kinase-3 beta inhibitors protectagainst the acute lung injuries resulting from acute necrotizing pancreatitis

Jin, Hongzhong; Yang, Xiaojia; Zhao, Kailiang; Zhao, Liang; Chen, Chen; Yu, Jia.

Acta cir. bras; 34 (6), 2019

Abstract Purpose The research is intended for clarification of the efficacy as well as the underlying mechanism of GSK-3β inhibitors on the advancement of acute lung injuries in acute necrotizing pancreatitis (ANP) in rats. Methods Seventy-two rats were randomly divided into 6 groups: (1)ANP-veh...

Lesión Pulmonar Aguda/etiología, Lesión Pulmonar Aguda/metabolismo, Lesión Pulmonar Aguda/patología, Lesión Pulmonar Aguda/prevención & control, Modelos Animales de Enfermedad, Glucógeno Sintasa Quinasa 3 beta/antagonistas & inhibidores, Inmunohistoquímica, Interleucina-1beta/metabolismo, FN-kappa B/metabolismo, Pancreatitis Aguda Necrotizante/complicaciones, Pancreatitis Aguda Necrotizante/patología, Fosforilación, Ratas Wistar, Transducción de Señal, Factor de Necrosis Tumoral alfa/metabolismo

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Effects of propofol pretreatment on lung morphology and heme oxygenase-1 expression in oleic acid-induced acute lung injury in rats

Abstract Purpose: To investigate the effects of propofol pretreatment on lung morphology and heme oxygenase-1 expression in oleic acid -induced acute lung injury in rats. Methods: A total of 32 male Sprague-Dawley rats (250-300g) were randomly divided into the following four groups (n=8/group): group...