Metformin is a hypoglycemic agent used as the first line for the treatment of non-insulin dependent Diabetes Mellitus. While it is a generally safe drug, it has an infrequent adverse reaction called lactic acidosis. We report a 49 year-old patient with non-insulin-requiring
type 2diabetes who developed a...
SUMMARY: The toxic effects of thioacetamide (TAA) and carbon tetrachloride on the human body are well recognized. In this study, we examined whether TAA intoxication can induce kidney leukocyte infiltration (measured as leukocyte common antigen CD45) associated with the augmentation of the reactive oxyge...
Metformina/uso terapéutico,
Lesión Renal Aguda/tratamiento farmacológico,
Lesión Renal Aguda/inducido químicamente,
Tioacetamida/toxicidad,
Hipoglucemiantes/uso terapéutico,
Especies Reactivas de Oxígeno,
Antígenos Comunes de Leucocito,
Factor de Necrosis Tumoral alfa,
Inflamación,
Inmunohistoquímica,
Biomarcadores
SUMMARY: To investigate if the administration of boric acid (BA) would exert any protective effect against possible nephrotoxicity and hepatotoxicity induced by the exposure to acrylamide (ACR) in rats. In our study, we used a total of 28 rats that were divided into four equal groups. Group 1: the contro...
Ácidos Bóricos/administración & dosificación,
Lesión Renal Aguda/prevención & control,
Lesión Renal Aguda/inducido químicamente,
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control,
Acrilamida/toxicidad,
Sustancias Protectoras/administración & dosificación,
Hígado/efectos de los fármacos,
Riñón/efectos de los fármacos,
Lesión Renal Aguda/patología,
Enfermedad Hepática Inducida por Sustancias y Drogas/patología,
Bioquímica,
Riñón/fisiopatología,
Hígado/fisiopatología
Abstract Background Compound A is generated by sevoflurane when it reacts with carbon dioxide absorbers with strong bases at minimal fresh gas flow (FGF) and is nephrotoxic in animals. No conclusive data has shown increased risk in humans. The aim of this study was to investigate if minimal FGF promotes...
Costa, Marcus Felipe Bezerra da;
Sampaio, Tiago Lima;
Azevedo, Isabella Evelyn Prado de;
Bandeira, Dânya Lima;
Soares, Igor Lima;
Meneses, Gdayllon Cavalcante;
Ribeiro, Samilly Albuquerque;
Evangelista, Janaina Serra Azul Monteiro;
Bandeira, Mary Anne Medeiros;
Libório, Alexandre Braga;
Martins, Alice Maria Costa.
Abstract Ischemia/reperfusion injury (I/R) is commonly related to acute kidney injury (AKI) and oxidative stress. Antioxidant agents are used to treat this condition. Lippia sidoides is a brazillian shrub with anti-inflammatory and anti-oxidative properties. Thus, the aim of this study is to evaluate the...
Hypericum/efectos adversos,
Lesión Renal Aguda/inducido químicamente,
Isquemia/clasificación,
Antioxidantes/administración & dosificación,
Citometría de Flujo/métodos,
d0183840,
Lesión Renal Aguda/complicaciones,
Macaca mulatta,
Medicina de Hierbas/instrumentación,
d0154240,
d0154270
Yoshida, Edson Hideaki;
Dini, Murilo Melo Juste;
Oliveira, Isadora Caruso Fontana;
Matiello Filho, José Antonio;
Cogo, José Carlos;
Cruz-Hofling, Maria Aliceda;
Grotto, Denise;
Hyslop, Stephen;
Yoshida, Valquíria Miwa Hanai;
Oshima, Franco Yoko.
Abstract Acute kidney injury (AKI) is the major cause of mortality following bites by the South American rattlesnake Crotalus durissus terrificus. We investigated the early onset of Crotalus durissus terrificus venom-induced AKI in rats within 2 h of venom injection and its attenuation by antivenom. Seve...
Gentamicin induced acute nephrotoxicity (GIAN) is considered as one of the important causes of acute renal failure. In recent years’ great effort has been focused on the introduction of herbal medicine as a novel therapeutic agent for prevention of GIAN. Hence, the current study was designed to investi...
Coffea/química,
Riñón/efectos de los fármacos,
Gentamicinas/toxicidad,
Extractos Vegetales/administración & dosificación,
Café,
Pruebas de Función Renal,
Ratas Wistar,
Estrés Oxidativo/efectos de los fármacos,
Riñón/patología,
Antioxidantes/administración & dosificación,
Malondialdehído/análisis,
Superóxido Dismutasa/análisis,
Lesión Renal Aguda/inducido químicamente,
Lesión Renal Aguda/prevención & control,
Extractos Vegetales/farmacología,
Antioxidantes/farmacología
Yildirim, Yasar;
Bahadir, Veysi;
Aydin, Emre;
Aydin, Fatma Yilmaz;
Yilmaz, Zülfükar;
Ketani, Aydin;
Kaplan, Ibrahim;
Tuncer, Mehmet Cudi;
Kadiroglu, Ali Kemal;
Yilmaz, Mehmet Emin.
SUMMARY: N-Acetylcysteine (NAC) is used for contrast induced acut kidney injury (CI-AKI) prophylaxis because of its antioxidant effects. Paricalcitol, which has reno-protective effects, is likely to provide a more effective prophylaxis when added to NAC treatment. The study was designed based on this hyp...
Lesión Renal Aguda/prevención & control,
Lesión Renal Aguda/inducido químicamente,
Medios de Contraste/efectos adversos,
Ergocalciferoles/administración & dosificación,
Ergocalciferoles/farmacología,
Acetilcisteína/administración & dosificación,
Acetilcisteína/farmacología,
Antioxidantes/administración & dosificación,
Antioxidantes/farmacología,
Estrés Oxidativo/efectos de los fármacos,
Ratas Wistar
ABSTRACT A wide spectrum of renal complications can occur with acute and chronic use of cocaine. Most cases are related to rhabdomyolysis, but other mechanisms are malignant hypertension, renal ischemia, and rapidly progressive glomerulonephritis (RPGN) associated-ANCA vasculitis. In recent years, the us...
