Strong renal expression of heat shock protein 70, high mobility group box 1, inducible nitric oxide synthase, and nitrotyrosine in mice model of severe malaria
Rev. Soc. Bras. Med. Trop; 50 (4), 2017
Abstract INTRODUCTION Renal damage is a consequence of severe malaria, and is generally caused by sequestration of Plasmodium falciparum -infected erythrocytes in the renal microcirculation, which leads to obstruction, hypoxia, and ischemia. This triggers high mobility group box 1 (HMGB1) to send a dang...
Lesión Renal Aguda/parasitología, Modelos Animales de Enfermedad, Proteína HMGB1/metabolismo, Proteínas HSP70 de Choque Térmico/metabolismo, Malaria/complicaciones, Malaria/metabolismo, Ratones, Ratones Endogámicos C57BL, Óxido Nítrico Sintasa de Tipo II/metabolismo, Índice de Severidad de la Enfermedad, Tirosina/antagonistas & inhibidores, Tirosina/metabolismo