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Edaravone improves the post-traumatic brain injury dysfunction in learning and memory by modulating Nrf2/are signal pathway

Li, Xiushan; Yu, Jing; Ma, Dongzhou; Weng, Xuehui.
Clinics; 76 (), 2021
OBJECTIVES: To investigate the molecular mechanism of edaravone (EDA) in improving the post-traumatic brain injury (TBI) dysfunction in learning and memory. METHODS: In vitro and in vivo TBI models were established using hydrogen peroxide (H2O2) treatment for hippocampal nerve stem cells (NSCs) and surg...
Elementos de Respuesta Antioxidante, Apoptosis/efectos de los fármacos, Lesiones Traumáticas del Encéfalo/tratamiento farmacológico, Lesiones Traumáticas del Encéfalo/metabolismo, Lesiones Traumáticas del Encéfalo/fisiopatología, Edaravona/farmacología, Aprendizaje/efectos de los fármacos, Memoria/efectos de los fármacos, Factor 2 Relacionado con NF-E2/metabolismo, Estrés Oxidativo/efectos de los fármacos, Especies Reactivas de Oxígeno/metabolismo, Transducción de Señal/efectos de los fármacos
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Octreotide-mediated neurofunctional recovery in rats following traumatic brain injury. Role of H2S, Nrf2 and TNF-α

Zhou, Jie; Cao, Li; Feng, Xia; Zhou, Baosheng; Li, Linshan.
Acta cir. bras; 36 (12), 2021
ABSTRACT Purpose: To explore the role and mechanisms of octreotide in neurofunctional recovery in the traumatic brain injury (TBI) model. Methods: Rats were subjected to midline incision followed by TBI in the prefrontal cortex region. After 72 hours, the behavioural and neurological deficits tests wer...
Lesiones Traumáticas del Encéfalo/tratamiento farmacológico, Sulfuro de Hidrógeno/metabolismo, Sulfuro de Hidrógeno/farmacología, Factor 2 Relacionado con NF-E2, Octreótido/farmacología, Factor de Necrosis Tumoral alfa
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Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1

Xu, Jianjun; Zhan, Tian; Zheng, Wan; Huang, Yun-Ke; Chen, Ken; Zhang, Xian-Hua; Ren, Ping; Huang, Xi.
Acta cir. bras; 35 (12), 2020
Abstract Purpose: To investigate the therapeutic benefits of Hydroxysafflor yellow A (HSYA) on blood-brain barrier (BBB) vulnerability after traumatic brain injury (TBI) and identify its potential action of mechanisms on TBIinduced injuries. Methods: The rat TBI model was performed by using a controlle...
Apoptosis, Barrera Hematoencefálica, Lesiones Traumáticas del Encéfalo/tratamiento farmacológico, Chalcona/análogos & derivados, Inflamación/tratamiento farmacológico, Estrés Oxidativo, Permeabilidad, Quinonas
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Traumatic brain injury pharmacological treatment: recommendations

Anghinah, Renato; Amorim, Robson Luís Oliveira de; Paiva, Wellingson Silva; Schmidt, Magali Taino; Ianof, Jéssica Natuline.
Arq. neuropsiquiatr; 76 (2), 2018
ABSTRACT This article presents the recommendations on the pharmacological treatment employed in traumatic brain injury (TBI) at the outpatient clinic of the Cognitive Rehabilitation after TBI Service of the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil. A systemati...
Antidepresivos/uso terapéutico, Lesiones Traumáticas del Encéfalo/tratamiento farmacológico, Lesiones Traumáticas del Encéfalo/rehabilitación, Disfunción Cognitiva/tratamiento farmacológico, Disfunción Cognitiva/rehabilitación, Pruebas Neuropsicológicas, Neurotransmisores/uso terapéutico, Guías de Práctica Clínica como Asunto, Reproducibilidad de los Resultados, Índices de Gravedad del Trauma
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Critical Analysis of Sedation and Analgesia in Severe Head Trauma

Rabelo, Nícollas Nunes; Rabelo, Neiffer Nunes; Machado, Fabio Santana; Joaquim, Marcos Augusto Stávale; Junior, Luiz Antônio Araujo Dias; Pereira, Carlos Umberto.
Arq. bras. neurocir; 35 (2), 2016
Introduction Head injury is a direct determinant of morbidity, disability, and mortality in the young population. Sedatives and analgesics are commonly used in patients with brain injury to retrieve an ICP, CMRO2, and CBF, preserving the cerebral regulation system and self-avoiding hypotension. Objective...
Analgesia, Lesiones Traumáticas del Encéfalo, Analgesia/efectos adversos, Sedación Profunda, Lesiones Traumáticas del Encéfalo/tratamiento farmacológico
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