LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Telomere length analysis in monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia Binet A

Furtado, FM; Scheucher, PS; Santana, BA; Scatena, NF; Calado, RT; Rego, EM; Matos, DM; Falcão, RP.

Braz. j. med. biol. res; 50 (5), 2017

Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic clinical entity characterized by the proliferation of monoclonal B cells not meeting the diagnosis criteria for chronic lymphocytic leukemia (CLL). MBL may precede the development of CLL, but the molecular mechanisms responsible for disease progres...

Factores de Edad, Linfocitos B/patología, Estudios de Casos y Controles, Progresión de la Enfermedad, Citometría de Flujo, Marcadores Genéticos, Leucemia Linfocítica Crónica de Células B/genética, Leucemia Linfocítica Crónica de Células B/patología, Recuento de Linfocitos, Linfocitosis/genética, Linfocitosis/patología, Estándares de Referencia, Estadísticas no Paramétricas, Telómero/patología, Acortamiento del Telómero/genética

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Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia

Introduction: monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x10(9)/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital s...