Abstract The aim of this study was to compare the dissolution properties of ibuprofen solid oral dosage forms commercially available in Bosnia and Herzegovina and to estimate the influence of dissolution medium composition on the drug release. Eight products (A-H) were subjected to in vitro dissolution t...
Zhang, Ying;
Pi, Jiaxin;
Li, Wen;
Zhang, Ludan;
Ma, Xutong;
Kebebe, Dereje;
Qi, Dongli;
Li, Nan;
Guo, Pan;
Liu, Zhidong.
Abstract Tongluo-Qutong rubber plaster (TQRP), a typical Chinese patent medicine that contains 13 different herbal remedies, is widely used in clinical practice for the treatment of cervical spondylosis and osteoarthritis. However, due to a lack of in vitro transdermal studies, the active ingredients of...
For a drug to excerpt pharmacological action after oral intake, it first needs to be released from the formulation, get into solution (dissolve), be absorbed, and reach the systemic circulation. Since only solubilized drugs can be absorbed, and thus have therapeutic effect, the understanding of the disso...
Optimización de Procesos,
Acciones Farmacológicas,
Composición de Medicamentos,
Concentración de Iones de Hidrógeno,
Desarrollo de Medicamentos/instrumentación,
Eficiencia,
Liberación de Fármacos,
Metronidazol/efectos adversos,
Necesidades y Demandas de Servicios de Salud/clasificación,
Preparaciones Farmacéuticas/análisis,
Química Farmacéutica/instrumentación,
Disolución
Abstract The objective of the present investigation was to design, optimize and characterize the gastro retentive floating levofloxacin tablets and perform in-vivo evaluation using radiographic imaging. The floating tablets were prepared by using polymers i.e hydroxy propyl methyl cellulose (HPMC-K4M) an...
Abstract Risperidone is an atypical antipsychotic drug widely prescribed all over the world due to its clinical advantages. The currently available long acting marketed depot formulation of risperidone is a microsphere based preparation using poly-[lactide-co-glycolide] (PLGA) as drug release barrier. It...
Abstract Periodontitis is an oral disease associated with inflammation and pain with swollen and bleeding gums. In the present study, dental pastes containing NSAIDs, namely, diclofenac sodium and nimesulide (1 % w/w) were prepared to treat periodontitis. Dental pastes of diclofenac sodium and nimesulide...
Pastas de Dientes/análisis,
Diclofenaco/efectos adversos,
Antiinflamatorios no Esteroideos/análisis,
Boca,
Enfermedad/clasificación,
Espectroscopía Infrarroja por Transformada de Fourier,
Encía/anomalías,
Inflamación/complicaciones,
Liberación de Fármacos,
Mucosa Bucal/anomalías,
Periodontitis,
Preparaciones Farmacéuticas,
Técnicas In Vitro/métodos
To overcome the problems associated with bioavailability and systemic side effects of the drug by oral administration, monolithic matrix type transdermal patches containing cinnarizine (CNZ) were developed. For this purpose, films based on hydroxypropyl methylcellulose and polyvinylpyrrolidone as matrix-...
Nizatidine is an anti-secretogogue and a gastroprotective drug with a half-life of 1-2 h and is well absorbed in the stomach. This study aimed to optimize the process and develop floating microparticles of nizatidine that are based on low methoxyl pectin. Oil-in-oil dispersion method and Taguchi orthogon...
Abstract In the recent past, drug delivery through nanoparticles is considered an effective tool to treat various diseases. Biopolymeric nanoparticles such as protein based nanoparticles have vital role as drug carrier as it is non-antigenic, and easily biodegradable. Curcumin, plant polyphenolic antican...
Técnicas In Vitro,
Nanopartículas,
Caseínas,
Curcumina,
Apoptosis,
Concentración 50 Inhibidora,
Células A549,
Liberación de Fármacos,
Antineoplásicos/farmacología,
Curcumina/farmacocinética,
Antineoplásicos/farmacocinética
Abstract The present study is aimed to formulate steroidal oral mucoadhesive gels of dexamethasone sodium phosphate and betamethasone sodium phosphate. Six gel formulations each of dexamethasone sodium phosphate and betamethasone sodium phosphate prepared using two different polymers carboxymethyl cellul...
