Home > LILACS - Literatura Latinoamericana y del Caribe de Ciencias de la Salud > Search result

Results: 3

Macromolecular confinement of therapeutic protein in polymeric particles for controlled release: insulin as a case study

Guerreiro, Luiz Henrique; Silva, Daniel da; Girard-Dias, Wendell; Mascarenhas, Camile Moreira; Miranda, Kildare; Sola-Penna, Mauro; Ricci Júnior, Eduardo; Lima, Luís Mauricio Trambaioli da Rocha e.
Braz. J. Pharm. Sci. (Online); 53 (2), 2017
ABSTRACT Sustained release systems for therapeutic proteins have been widely studied targeting to improve the action of these drugs. Molecular entrapping of proteins is particularly challenging due to their conformational instability. We have developed a micro-structured poly-epsilon-caprolactone (PCL) p...
Insulina/análisis, Liberación de Fármacos/fisiología, Material Particulado/farmacología, Microscopía Electrónica/22074, Hipoglucemiantes/farmacología, Preparaciones Farmacéuticas/administración & dosificación, Diabetes Mellitus/prevención & control
Fulltext

Development of enteric coated sustained release minitablets containing mesalamine

Souza, Dayse Fernanda de; Goebel, Karin; Andreazza, Itamar Francisco.
Braz. j. pharm. sci; 49 (3), 2013
The aim of this study was to develop and evaluate a multiparticulate modified release system, composed of minitablets with a sustained release matrix system coated with a pH-dependent release polymer, using mesalamine as a model drug. Polyox® WSR 1105 was the polymer used in the matrix system and Eudrag...
Mesalamina/análisis, Comprimidos Recubiertos/análisis, Liberación de Fármacos/fisiología
Fulltext

Floating tablets of hydralazine hydrochloride: optimization and evaluation

Vanitha, Kondi; Varma, Mohan; Ramesh, Alluri.
Braz. j. pharm. sci; 49 (4), 2013
Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy. The purpose of this study was to optimize and evaluate floating ta...
Comprimidos/análisis, Hidralazina/clasificación, 51780/clasificación, Optimización de Procesos/clasificación, Hidralazina/análisis, Liberación de Fármacos/fisiología, Neoplasias Primarias Secundarias
Fulltext