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A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny

Aldrovani, Marcela; Filezio, Marcella Rosa; Laus, José Luiz.
Arq. bras. oftalmol; 80 (4), 2017
ABSTRACT Various approaches have been taken to improve our knowledge of the microenvironmental regulation of limbal epithelial stem cells. Researchers have extensively investigated the roles of growth factors, survival factors, cytokines, enzymes, and permeable molecules secreted by the limbal cells. How...
Diferenciación Celular/fisiología, Epitelio Corneal/citología, Epitelio Corneal/fisiología, Matriz Extracelular/fisiología, Limbo de la Córnea/citología, Mecanotransducción Celular/fisiología, Nicho de Células Madre/fisiología, Células Madre/fisiología
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Assessment of surgical outcomes of limbal transplantation using simple limbal epithelial transplantation technique in patients with total unilateral limbal deficiency

Queiroz, Ana Gabriela; Barbosa, Martina Maria Oiticica; Santos, Myrna Serapião; Barreiro, Telma Pereira; Gomes, José Álvaro Pereira.
Arq. bras. oftalmol; 79 (2), 2016
ABSTRACT This study aimed to evaluate the effectiveness of the novel simple limbal epithelial transplantation (SLET) technique, which reduces the risk of iatrogenic limbal stem cell deficiency in the donor eye. Four patients with total unilateral limbal stem cell deficiency received a limbal graft, measu...
Enfermedades de la Córnea/cirugía, Epitelio Corneal/citología, Epitelio Corneal/trasplante, Quemaduras Oculares/cirugía, Limbo de la Córnea/citología, Periodo Posoperatorio, Trasplante de Células Madre/métodos, Trasplante Autólogo/métodos, Resultado del Tratamiento, Agudeza Visual
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