Abnormal expression of b10 cell frequencies: possible relation to pathogenesis and disease severity of aplastic anemia
Rev. Assoc. Med. Bras. (1992, Impr.); 65 (5), 2019
SUMMARY OBJECTIVE: Aplastic anemia (AA) is an immune-mediated disease that destroys hematopoietic cells through activated T lymphocytes. B lymphocyte-mediated humoral immunity also plays an important role in the pathogenesis of AA. Regulatory B cell (Breg) subpopulation, which is defined as "B10", secre...
Anemia Aplásica/sangre, Anemia Aplásica/patología, Antígenos CD19/análisis, Antígenos CD19/metabolismo, Linfocitos B Reguladores/patología, Células de la Médula Ósea/citología, Estudios de Casos y Controles, Células Cultivadas, Citometría de Flujo, Técnica del Anticuerpo Fluorescente, Interleucina-10/análisis, Interleucina-10/metabolismo, Recuento de Leucocitos, Persona de Mediana Edad, Neutrófilos, Valores de Referencia, Recuento de Reticulocitos, Índice de Severidad de la Enfermedad