Results: 4

The role of regulatory T cells, interleukin-10 and in vivo scintigraphy in autoimmune and idiopathic diseases - Therapeutic perspectives and prognosis

Summary Previous studies have demonstrated the expression of the CD25 marker on the surface of naturally occurring T cells (Tregs) of mice, which have a self-reactive cellular profile. Recently, expression of other markers that aid in the identification of these cells has been detected in lymphocyte subt...

Circulating myeloid-derived suppressor cells predict disease activity and treatment response in patients with immune thrombocytopenia

Braz. j. med. biol. res; 50 (2), 2017
Immune thrombocytopenia (ITP) is a disease characterized by isolated thrombocytopenia. Abnormal effector T cell activation is an important mechanism in the pathogenesis of ITP. Regulatory T cells (Treg) have a strong immunosuppressive function for T cell activation and their importance in the pathophysio...

Programmed cell death 5 transgenic mice attenuates adjuvant induced arthritis by 2 modifying the T lymphocytes balance

Biol. Res; 50 (), 2017
BACKGROUND: Programmed cell death 5 (PDCD5) is an apoptosis-related gene cloned from TF-1 cells whose primary biological functions are to promote apoptosis and immune regulation. The effects and mechanisms exerted by key mediators of arthritic inflammation remain unclear in PDCD5 transgenic (PDCD5 tg) mi...

The role of Th17 and regulatory T cells (TREGs) in immunomodulation of experimental periapical lesions

A patogênese das lesões periapicais é determinada pelo equilíbrio entre a resposta imune pró-inflamatória do hospedeiro e a resposta anti-inflamatória/reparo. Diferentes subtipos de linfócitos e seus produtos têm sido implicados na patogênese dessas lesões, tais como as células T reguladoras ...