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Synthesis and In Vivo Hypolipidemic Effect of Some N-(Benzoylphenyl)-Carboxamide Derivatives in Triton WR-1339-Induced Hyperlipidemic Rats

Sweidan, Kamal; Sheikha, Ghassan Abu; Shattat, Ghassan; Al-qirim, Tariq; Bkhaitan, Majdi.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
A series of N-(benzoylphenyl)-carboxamide derivatives (2a, 2b, 3a, 3b, 4a, 4b, 5a, 5b, 6a and 6b) was prepared with good yields by reacting the corresponding carbonyl chlorides with aminobenzophenones at room temperature. This was followed by evaluating the hypotriglyceridemic and hypocholesterolemic eff...
Hipolipemiantes/síntesis química, Hipolipemiantes/farmacología, Hiperlipidemias/inducido químicamente, Lipoproteínas HDL/efectos de los fármacos, Lipoproteínas LDL/efectos de los fármacos, Modelos Animales de Enfermedad, Ratas Wistar, Piridinas/síntesis química, Piridinas/farmacología, Triglicéridos/sangre, Colesterol/sangre, Lípidos/sangre, Polietilenglicoles
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Lipid core nanoparticles resembling low-density lipoprotein and regression of atherosclerotic lesions: effects of particle size

Freitas, SCMP; Tavares, ER; Silva, BMO; Meneghini, BC; Kalil-Filho, R; Maranhão, RC.
Braz. j. med. biol. res; 51 (3), 2018
Particles are usually polydispersed and size is an important feature for lipid-based drug delivery systems in order to optimize cell-particle interactions as to pharmacologic action and toxicity. Lipid nanoparticles (LDE) with composition similar to that of low-density lipoprotein carrying paclitaxel wer...
Aterosclerosis/tratamiento farmacológico, Quimioterapia Combinada, Lípidos/administración & dosificación, Lipoproteínas LDL/efectos de los fármacos, Nanopartículas/administración & dosificación, Paclitaxel/administración & dosificación, Tamaño de la Partícula, Moduladores de Tubulina/administración & dosificación
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Efecto de los proteoglicanos arteriales sobre la oxidación in vitro de LDL aislada de pacientes hipercolesterolémicos
Effect of arterial proteoglycans on in vitro oxidation of LDL isolated from hypercholesterolemic patients

Barón, Luz; López, Flor.
Acta cient. venez; 51 (4), 2000
The interaction of LDL with extracellular matrix proteoglycan apparently contribute to the acumulation of apo B-lipoproteins in atherogenesis. Retention of LDL by intima proteoglycans appears to increase the residence time needed for their structural, hydrolytic and oxidative modification. If the rate of...
Proteoglicanos/farmacología, Lipoproteínas LDL/metabolismo, Hipercolesterolemia/metabolismo, Lipoproteínas LDL/efectos de los fármacos, Lipoproteínas LDL/aislamiento & purificación, Oxidación-Reducción, Aorta, Matriz Extracelular, Lípidos/sangre, Factores de Tiempo, Oxidantes/farmacología