LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Up-regulated miR-106b inhibits ox-LDL-induced endothelial cell apoptosis in atherosclerosis

This research aimed to explore the molecular mechanism of microRNA (miR)-106b in cell apoptosis of atherosclerosis (AS). Human aortic endothelial cells (HAECs) were divided into control group, oxidized-low-density lipoproteins (ox-LDL) group, miR-106b NC+ox-LDL group, miR-106b mimics+ox-LDL group, miR-10...

Associations of Cerebrovascular Metabolism Genotypes With Neuropsychiatric Symptoms and Age at Onset of Alzheimer's Disease Dementia

Oliveira, Fabricio F de; Chen, Elizabeth S; Smith, Marilia C; Bertolucci, Paulo H.

Braz. J. Psychiatry (São Paulo, 1999, Impr.); 39 (2), 2017

Objective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer’s disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia ons...

Edad de Inicio, Alelos, Enfermedad de Alzheimer/genética, Enfermedad de Alzheimer/metabolismo, Enfermedad de Alzheimer/fisiopatología, Apolipoproteínas E/genética, Trastornos Cerebrovasculares/genética, Trastornos Cerebrovasculares/metabolismo, Trastornos Cerebrovasculares/fisiopatología, Proteínas de Transferencia de Ésteres de Colesterol/genética, Estudios Transversales, Dosificación de Gen, Estudios de Asociación Genética, Genotipo, Enfermedades de Inicio Tardío, Modelos Lineales, Lipoproteínas LDL/genética, Receptores X del Hígado/genética, Pruebas Neuropsicológicas

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