Abstract Toll-like receptor 9 (TLR9) is an important component of the innate immune system and have been associated with several autoimmune diseases, such as Systemic Lupus Erythematosus (SLE). The aim of this study was to investigate polymorphisms in TLR9 gene in a Brazilian SLE patients group and their...
La autoinmunidad es la consecuencia de la pérdida de control y regulación de la respuesta inmune. Se re-porta que ocurre entre 5 y 9% de patologÃas a nivel mundial. A las enfermedades con esta anomalÃa se les denomina autoinmunes y se clasifican de acuerdo con el órgano o sistema afectado. Las reumÃ...
OBJECTIVES: Many studies indicate that microRNAs (miRNAs) could be potential biomarkers for various diseases. The purpose of this study was to investigate the clinical value of serum exosomal miRNAs in systemic lupus erythematosus (SLE). METHODS: Serum exosomes were isolated from 38 patients with SLE an...
Tumor necrosis factor-alpha (TNF-α) plays an important role in autoimmune diseases. Previous studies have investigated the association of TNF-α-238G/A (rs361525) and -308G/A (rs1800629) polymorphisms with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). However, no agreed concl...
Abstract Background Complement component 4 (C4) gene copy number (GCN) affects the susceptibility to systemic lupus erythematosus (SLE) in different populations, however the possible phenotype significance remains to be determined. This study aimed to associate C4A , C4B and total C4 GCN and SLE, focusi...
Garavito, Gloria;
Egea, Eduardo;
Fang, Luis;
Malagón, Clara;
Olmos, Carlos;
González, Luz;
Guarnizo, Pilar;
Aroca, Gustavo;
López, Guillermo;
Iglesias, Antonio.
RESUMEN Introducción. El lupus eritematoso sistémico es una enfermedad autoinmunitaria cuya gravedad varÃa según la raza, el sexo y la edad de aparición. Esta disparidad también se observa en los marcadores genéticos asociados con la enfermedad presentes en los genes PTPN22, VDR y TNF. La estrati...
Lupus Eritematoso Sistémico/complicaciones,
Nefritis Lúpica/complicaciones,
Polimorfismo de Nucleótido Simple/genética,
ProteÃna Tirosina Fosfatasa no Receptora Tipo 22/genética,
Receptores de Calcitriol/genética,
Factor de Necrosis Tumoral alfa/genética,
Alelos,
Colombia,
Genotipo,
Lupus Eritematoso Sistémico/genética,
Nefritis Lúpica/genética,
Polimorfismo de Nucleótido Simple/fisiologÃa,
ProteÃna Tirosina Fosfatasa no Receptora Tipo 22/quÃmica,
ProteÃna Tirosina Fosfatasa no Receptora Tipo 22/metabolismo,
Receptores de Calcitriol/quÃmica,
Receptores de Calcitriol/metabolismo,
Factor de Necrosis Tumoral alfa/quÃmica
Canto, Luisa Matos do;
Farias, Ticiana Della Justina;
Medeiros, Mayara Delagnelo;
Coêlho, CÃntia Callegari;
Sereia, Aline Fernanda Rodrigues;
Back, Lia Kubelka Fernandes de Carlos;
Mello, Filipe Martins de;
Zimmermann, Adriana Fontes;
Pereira, Ivânio Alves;
Souza, IlÃada Rainha de.
ABSTRACT Objective: This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A - rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population. Methods: Polymerase chain reaction-restricti...
ABSTRACT Objective: To investigate potential associations of four substitutions in NAT2 gene and of acetylator phenotype of NAT2 with systemic lupus erythematosus (SLE) and clinical phenotypes. Methods: Molecular analysis of 481C>T, 590G>A, 857G>A, and 191G>A substitutions in the NAT2 gene ...
ABSTRACT We evaluated the possible association between FCGR3A V/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerase chain reaction. Our results showed no a...
Introduction: Nucleic acid methylation may have major effects on gene expression patterns and, by consequence, on the development of autoimmunity, like Systemic Lupus Erythematosus (SLE). Objective: To investigate the pattern of global DNA methylation in SLE patients and compare this pattern with laborat...
