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Inhibition of nitric oxide production of activated mice peritoneal macrophages is independent of the Toxoplasma gondii strain

Damasceno-Sá, João Cláudio; de Souza, Fernanda Silva; dos Santos, Thiago Alves Teixeira; de Oliveira, Fábio Conceição; da Silva, Maria de Fátima Sarro; Dias, Raul Ramos Furtado; de Souza, Wanderley; Arnholdt, Andrea Cristina Veto; Seabra, Sergio Henrique; DaMatta, Renato Augusto.
Mem. Inst. Oswaldo Cruz; 116 (), 2021
BACKGROUND Toxoplasma gondii causes toxoplasmosis and is controlled by activated macrophages. However, infection of macrophages by tachyzoites induces TGF-β signaling (TGF-s) inhibiting nitric oxide (NO) production. NO inhibition may be a general escape mechanism of distinct T. gondii strains. OBJE...
Macrófagos/metabolismo, Macrófagos/parasitología, Macrófagos Peritoneales/parasitología, Óxido Nítrico/biosíntesis, Óxido Nítrico Sintasa/metabolismo, Toxoplasma/fisiología, Toxoplasmosis Animal/parasitología
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Antimonial drugs entrapped into phosphatidylserine liposomes: physicochemical evaluation and antileishmanial activity

Borborema, Samanta Etel Treiger; Osso Junior, João Alberto; Andrade Junior, Heitor Franco de; Nascimento, Nanci do.
Rev. Soc. Bras. Med. Trop; 49 (2), 2016
Abstract: INTRODUCTION: Leishmaniasis is a disease caused by the protozoan Leishmania that resides mainly in mononuclear phagocytic system tissues. Pentavalent antimonials are the main treatment option, although these drugs have toxic side effects and high resistance rates. A potentially alternative an...
Gluconato de Sodio Antimonio/química, Gluconato de Sodio Antimonio/farmacología, Antiprotozoarios/química, Antiprotozoarios/farmacología, Cricetinae, Relación Dosis-Respuesta a Droga, Concentración 50 Inhibidora, Leishmania infantum/efectos de los fármacos, Liposomas, Macrófagos Peritoneales/parasitología, Meglumina/química, Meglumina/farmacología, Antimoniato de Meglumina, Ratones, Ratones Endogámicos BALB C, Compuestos Organometálicos/química, Compuestos Organometálicos/farmacología, Pruebas de Sensibilidad Parasitaria, Fosfatidilserinas/química, Fosfatidilserinas/farmacología
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Sodium nitroprusside has leishmanicidal activity independent of iNOS

Kawakami, Natália Yoshie; Tomiotto-Pellissier, Fernanda; Cataneo, Allan Henrique Depieri; Orsini, Tatiane Marcusso; Thomazelli, Ana Paula Fortes Dos Santos; Panis, Carolina; Conchon-Costa, Ivete; Pavanelli, Wander Rogério.
Rev. Soc. Bras. Med. Trop; 49 (1), 2016
Abstract: INTRODUCTION: Leishmaniasis is a zoonotic disease caused by protozoa of the genus Leishmania . Cutaneous leishmaniasis is the most common form, with millions of new cases worldwide each year. Treatments are ineffective due to the toxicity of existing drugs and the resistance acquired by certain...
Inmunohistoquímica, Macrófagos Peritoneales/parasitología, Ratones, Ratones Endogámicos BALB C, Óxido Nítrico/biosíntesis, Nitroprusiato/farmacología, Tripanocidas/farmacología, Tirosina/análogos & derivados, Tirosina/biosíntesis, Tirosina/efectos de los fármacos
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