Bashir, Salah O;
Morsy, Mohamed D;
Mohammed, Muataz E;
Abbas, Amr M;
Badi, Rehab M;
Osman, Osama M;
Dawood, Amal F;
Saeed, Amal M;
Eid, Refaat A;
Sabir, Deema K.
SUMMARY: This study assessed the effects of Acacia Senegal (AS) combined with insulin on Na+/K+-ATPase (NKA) activity and mRNA expression, serum glucose, renal function, and oxidative stress in a rat model of diabetic nephropathy (DN). Sixty rats were equally divided into six groups: normal control, norm...
Acacia/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Nefropatías Diabéticas/tratamiento farmacológico,
ATPasa Intercambiadora de Sodio-Potasio/efectos de los fármacos,
ATPasa Intercambiadora de Sodio-Potasio/genética,
Estrés Oxidativo,
Control Glucémico,
Insulina/administración & dosificación,
Quimioterapia Combinada,
Expresión Génica,
Malondialdehído,
Superóxido Dismutasa,
Modelos Animales de Enfermedad,
Ratas Sprague-Dawley,
Riñón/efectos de los fármacos,
Microscopía Electrónica de Transmisión,
Hemoglobina Glucada/análisis,
d0123330
SUMMARY: Cisplatin (Cis) is an important chemotherapeutic agent used in cancer treatment. Males exposed to Cis were reported to exhibit testicular toxicity. Cis-induced testicular toxicity is mediated by oxidative stress, inflammation, testosterone inhibition and apoptosis. Accordingly, this study was co...
Camellia sinensis/química,
Extractos Vegetales/farmacología,
Té/química,
Infliximab/farmacología,
Cisplatino/toxicidad,
Testículo/efectos de los fármacos,
Recuento de Espermatozoides,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores,
Apoptosis,
Estrés Oxidativo,
Inflamación,
Ratas Sprague-Dawley,
Extractos Vegetales/química,
Inmunohistoquímica,
Malondialdehído/análisis,
Glutatión/análisis,
Testículo/patología
Oxidative stress is identified as the common pathogenic factor that leads to insulin resistance in diabetics. Malondialdehyde is a product of lipid peroxidation. Aim: The aim of this study was to determine the variation in the Salivary malondialdehyde (MDA) among subjects with and without T2DM in compari...
SUMMARY: An association between certain food additives and chronic diseases is reported. Current study determined whether administering toxic doses of the food additive monosodium glutamate (MSG) into rats can induce aortopathy in association with the oxidative stress and inflammatory biomarkers upregula...
Aorta/efectos de los fármacos,
Vitamina E/farmacología,
Glutamato de Sodio/toxicidad,
Enfermedades de la Aorta/inducido químicamente,
Estrés Oxidativo/efectos de los fármacos,
Modelos Animales de Enfermedad,
Microscopía Electrónica,
Aorta/patología,
Vitamina E/administración & dosificación,
Glutamato de Sodio/administración & dosificación,
Ratas Sprague-Dawley,
Malondialdehído/antagonistas & inhibidores,
Interleucina-6/antagonistas & inhibidores,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
Gentamicin induced acute nephrotoxicity (GIAN) is considered as one of the important causes of acute renal failure. In recent years’ great effort has been focused on the introduction of herbal medicine as a novel therapeutic agent for prevention of GIAN. Hence, the current study was designed to investi...
Coffea/química,
Riñón/efectos de los fármacos,
Gentamicinas/toxicidad,
Extractos Vegetales/administración & dosificación,
Café,
Pruebas de Función Renal,
Ratas Wistar,
Estrés Oxidativo/efectos de los fármacos,
Riñón/patología,
Antioxidantes/administración & dosificación,
Malondialdehído/análisis,
Superóxido Dismutasa/análisis,
Lesión Renal Aguda/inducido químicamente,
Lesión Renal Aguda/prevención & control,
Extractos Vegetales/farmacología,
Antioxidantes/farmacología
SUMMARY: Carbon tetrachloride (CCl4) is a manufactured chemical and does not occur naturally in the environment. CCl4 is a clear liquid that evaporates very easily. It has a sweet odor. CCl4 is toxic to the mammalian liver and is hepatocarcinogenic in both rats and mice. Rosemary (Rosmarinus Officinalis)...
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico,
Cinamatos/administración & dosificación,
Depsidos/administración & dosificación,
Antioxidantes/administración & dosificación,
Tetracloruro de Carbono/toxicidad,
Inmunohistoquímica,
Estrés Oxidativo/efectos de los fármacos,
Microscopía Electrónica de Transmisión,
Cinamatos/farmacología,
Depsidos/farmacología,
Antioxidantes/farmacología,
Malondialdehído/análisis,
Glutatión Peroxidasa/análisis,
Superóxido Dismutasa/análisis
Abstract The study aimed to assess possible spirulina effects on lipid profile, glucose, and malondialdehyde levels in new cases of type 2 diabetes. The subjects consisted of 30 new cases of types 2 diabetes that divided into two groups; each consisted of 15 diabetic patients. Group I did not take any fu...
ABSTRACT Introduction: Although the efficacy of hydroxyurea (HU) in inhibiting erythrocyte sickling has been well demonstrated, the action of this drug on human neutrophils and the mechanism by which it improves the manifestations of the disease have not been studied thoroughly. We aimed to investigate ...
Abstract Introduction: In this study, patients before and after cardiac surgery with cardiopulmonary bypass (CPB) and control subjects were evaluated for erythrocyte glutathione peroxidase, catalase and superoxide dismutase enzyme activities, in addition to glutathione, malondialdehyde, serum total sial...
ABSTRACT: Despite the reported effects of smokeless tobacco (ST) on the periodontium and high prevalence of ST use in rural populations and in males studies on this specific topic are limited. The purpose of this cross-sectional investigation was to measure lipid peroxidation (as an end product of oxidat...