Introducción: El género Brucella está incluido en la familia Brucellaceae que pertenece al orden Rhizobiales y es reconocido por su alto grado de patogenicidad. Las bacterias de este género son responsables de la brucelosis, enfermedad que ha sido reportada como una de las zoonosis más importantes ...
Abstract Long-chain non-encoded RNAs (lncRNAs) are important in many life activities and can participate in the occurrence of hepatocellular carcinoma (HCC). Moreover, lncRNAs can be used as basis for developing new strategies to hinder liver cancer. To investigate the utility of lncRNAs in HCC as potent...
Bello, Graziele Lima;
Morais, Franciele Costa Leite;
de Jesus, Sheile Pinheiro;
Wolf, Jonas Michel;
Gehlen, Mirela;
de Almeida, Isabela Neves;
Figueiredo, Lida Jouca de Assis;
Soares, Tainá dos Santos;
Barcellos, Regina Bones;
Dalla Costa, Elis Regina;
de Miranda, Silvana Spíndola;
Rossetti, Maria Lucia Rosa.
BACKGROUND Early diagnosis of tuberculosis (TB) and identification of strains of Mycobacterium tuberculosis resistant to anti-TB drugs are considered the main factors for disease control. OBJECTIVES To standardise a real-time polymerase chain reaction (qPCR) assay technique and apply it to identify mu...
Antituberculosos/farmacología,
ADN Bacteriano/genética,
Farmacorresistencia Bacteriana/genética,
Marcadores Genéticos/genética,
Genotipo,
Isoniazida/farmacología,
Pruebas de Sensibilidad Microbiana,
Mutación/genética,
Mycobacterium tuberculosis/efectos de los fármacos,
Mycobacterium tuberculosis/genética,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Sensibilidad y Especificidad
Verdugo, Ricardo A;
Genova, Alex Di;
Herrera, Luisa;
Moraga, Mauricio;
Acuña, Mónica;
Berríos, Soledad;
Llop, Elena;
Valenzuela, Carlos Y;
Bustamante, M. Leonor;
Digman, Dayhana;
Symon, Adriana;
Asenjo, Soledad;
López, Pamela;
Blanco, Alejandro;
Suazo, José;
Barozet, Emmanuelle;
Caba, Fresia;
Villalón, Marcelo;
Alvarado, Sergio;
Cáceres, Dante;
Salgado, Katherine;
Portales, Pilar;
Moreno-Estrada, Andrés;
Gignoux, Christopher R;
Sandoval, Karla;
Bustamante, Carlos D;
Eng, Celeste;
Huntsman, Scott;
Burchard, Esteban G;
Loira, Nicolás;
Maass, Alejandro;
Cifuentes, Lucía.
BACKGROUND: Current South American populations trace their origins mainly to three continental ancestries, i.e. European, Amerindian and African. Individual variation in relative proportions of each of these ancestries may be confounded with socio-economic factors due to population stratification. Theref...
Etnicidad/genética,
Genética de Población/organización & administración,
Indígenas Sudamericanos/genética,
Polimorfismo de Nucleótido Simple/genética,
Grupos de Población/genética,
Frecuencia de los Genes/genética,
Marcadores Genéticos/genética,
Chile,
Genotipo,
Técnicas de Genotipaje,
Filogeografía,
Saliva
Abstract Cementum is the mineralized tissue covering the tooth root that functions in tooth attachment and post-eruptive adjustment of tooth position. It has been reported to be highly similar to bone in several respects but remains poorly understood in terms of development and regeneration. Here, we inv...
Proteínas Adaptadoras Transductoras de Señales,
Análisis de Varianza,
Proteínas Morfogenéticas Óseas/análisis,
Proteínas Morfogenéticas Óseas/genética,
Técnicas de Cultivo de Célula/métodos,
Línea Celular,
Cemento Dental/metabolismo,
Proteínas de la Matriz Extracelular/análisis,
Proteínas de la Matriz Extracelular/genética,
Técnica del Anticuerpo Fluorescente,
Expresión Génica,
Marcadores Genéticos/genética,
Glicoproteínas de Membrana/análisis,
Glicoproteínas de Membrana/genética,
Diente Molar/citología,
Fosfatos/farmacología,
Fosfoproteínas/análisis,
Fosfoproteínas/genética,
Sialoglicoproteínas/análisis,
Sialoglicoproteínas/genética,
Factores de Tiempo,
Cemento Dental/citología
Not much is known about the roles of long non-coding RNAs (lncRNAs) for chronic kidney disease (CKD). In this study, we included CKD patient cohorts and normal controls as a discovery cohort to identify putative lncRNA biomarkers associated with CKD. We first compared the lncRNA expression profiles of CK...
Abstract: Porphyria cutanea tarda has a complex etiology with genetic factors not completely elucidated. The miscegenation of the Brazilian population has important implications in the predisposition to diseases. There are no studies concerning the genetic ancestry of patients with porphyria cutanea tard...
ABSTRACT Objective Monocyte chemoattractant protein 1 (MCP-1) has been suggested to be involved in the pathophysiology of insulin resistance (IR); therefore, variants in the MCP-1 gene may contribute to the development of this disease. The aim of this study was to analyze the relationship of the -2518 A...
ABSTRACT Objective To verify the incidence of the G679A mutation in exon 2 of the gene inhibin alpha (INHA), in women with secondary amenorrhea and diagnosis of premature ovarian insufficiency, and in controls. Methods A 5mL sample of peripheral blood was collected from all study participants in an E...
