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Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells

Li, Musheng; Zhao, Junhong; Cao, Meiwan; Liu, Ruitao; Chen, Guanhua; Li, Songyu; Xie, Yuanwen; Xie, Jing; Cheng, Yang; Huang, Ling; Su, Mingmin; Xu, Yuxin; Zheng, Mingyue; Zou, Kejian; Geng, Lanlan; Xu, Wanfu; Gong, Sitang.
Biol. Res; 53 (), 2020
BACKGROUND: Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. However, the function of MCs in IBD remains to be fully elucidated. RESULTS: In our stu...
Células Epiteliales/metabolismo, Mucosa Intestinal/metabolismo, Mastocitos/metabolismo, MicroARNs/metabolismo, Células CACO-2/citología, Claudinas/metabolismo, Exosomas/metabolismo, Enfermedades Inflamatorias del Intestino/metabolismo, Ocludina/metabolismo, Proteína de la Zonula Occludens-1/metabolismo, Células Cultivadas, Biología Computacional, Permeabilidad, Análisis de Matrices Tisulares
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El papel de los mastocitos en la evaluación de la respuesta inflamatoria posoperatoria, al implantar mallas protésicas para la reparación de defectos de la pared abdominal en biomodelos rata Wistar

Arboleda C, Alejandro; Franco A, Manuel Hernando; Valladares T, Liliana.
Rev. chil. cir; 70 (2), 2018
Resumen Objetivo: El objetivo de este estudio fue evaluar el papel de los mastocitos en la respuesta inflamatoria posoperatoria tras el implante de mallas protésicas para la reparación de defectos de la pared abdominal en biomodelos rata Wistar. Materiales y Métodos: Se fabricó una malla de fibroma...
Mastocitos/metabolismo, Pared Abdominal/cirugía, Mallas Quirúrgicas, Serotonina/metabolismo, Ratas Wistar, Histamina/metabolismo, Inflamación, Modelos Animales
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Large Accumulation of Collagen and Increased Activation of Mast Cells in Hearts of Mice with Hyperlipidemia

Cheng, Yunpeng; Zhu, Yanqiu; Zhang, Jiashu; Duan, Xingping; Zhang, Ying.
Arq. bras. cardiol; 109 (5), 2017
Abstract Background: Hyperlipidemia, which is characterized by an elevation of lipids in the bloodstream, is a major risk factor for cardiac disease. Objectives: The present study investigated the role of fibrosis in the progression of hyperlipidemia in the mice heart, and whether mast cell activation ...
Western Blotting, Colágeno/metabolismo, Dieta Alta en Grasa/efectos adversos, Modelos Animales de Enfermedad, Fibrosis, Hiperlipidemias/etiología, Hiperlipidemias/metabolismo, Hiperlipidemias/patología, Inmunohistoquímica, Mastocitos/química, Mastocitos/metabolismo, Ratones Endogámicos C57BL, Miocardio/metabolismo, Miocardio/patología
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Histochemical and immunohistochemical differences between solitary oral fibroma and fibrous papule of the face

Henriques, Águida Cristina Gomes; Freitas, Roseana de Almeida; Pires, Bruno Cunha; Gurgel, Clarissa Araújo; Santos, Jean Nunes dos.
An. bras. dermatol; 91 (5), 2016
Abstract: Background: The morphological similarities between fibrous papules of the face and multiple sporadic oral fibromas were mentioned long ago and a relationship between them has been reported in the literature. Objective: The aim of this study was to evaluate the participation of mast cells, ela...
Dermatosis Facial/patología, Fibroma/patología, Colágeno/metabolismo, Elastina/metabolismo, Dermatosis Facial/metabolismo, Fibroblastos/metabolismo, Fibroma/metabolismo, Fibrosis/metabolismo, Inmunohistoquímica, Mastocitos/metabolismo, Mucosa Bucal/metabolismo, Triptasas/metabolismo
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