Objective: Evaluate the effectiveness of resveratrol as a hepatoprotector in a rat model of paracetamol-induced liver injury and its biodistribution to understand its pharmacokinetics. Methodology: As an experimental approach, animals were divided into the test group with 4 subgroups and the control grou...
Resumen Desde épocas ancestrales, las algas marinas han sido empleadas con fines medicinales. En la actualidad, las algas han atraído la atención como fuentes de compuestos bioactivos, debido a su alto contenido en metabolitos secundarios. En numerosos estudios epidemiológicos e investigaciones exper...
The article examines the influence of the Biologically Active Dietary Supplement (BADS) “Oleopren
Hepa” as a hepatoprotective effect in the comprehensive treatment of acute alcoholic hepatitis. During
the study, the authors obtained evidence of the effectiveness and functional orientation of the BADS...
This research was designed to investigate the potential protective effect of vitamin C supplementation against hepatocyte ultrastructural alterations induced by artemether (antimalarial drug) administration. Twenty-four adult male albino rats were used in this study and were divided into four groups (n=6...
Ácido Ascórbico/administración & dosificación,
Ácido Ascórbico/farmacología,
Enfermedad Hepática Crónica Inducida por Sustancias y Drogas/tratamiento farmacológico,
Arteméter/toxicidad,
Estrés Oxidativo/efectos de los fármacos,
Biomarcadores,
Hepatocitos/ultraestructura,
Modelos Animales de Enfermedad,
Ratas Sprague-Dawley,
Superóxido Dismutasa/análisis,
Glutatión Peroxidasa/análisis,
Microscopía Electrónica de Transmisión,
Enfermedad Hepática Inducida por Sustancias y Drogas/patología,
Hepatocitos/efectos de los fármacos,
Medicamentos Hepatoprotectores
Fruit purees can be added to diet as alternative sources of bioactive compounds for the prevention and/or improvement of the complications of metabolic syndrome. In this work we evaluated the effect of the intake of low-fat diets enriched with fruit purees (guava-strawberry, guava-blackberry, guava-sours...
Dieta con Restricción de Grasas,
Frutas,
Síndrome Metabólico,
Hígado/efectos de los fármacos,
Medicamentos Hepatoprotectores,
Biomarcadores,
Lípidos/análisis,
Transaminasas/análisis,
Fosfatasa Alcalina/análisis,
Albúminas/análisis,
Hígado/química,
Modelos Animales de Enfermedad,
Peso Corporal/efectos de los fármacos,
Glucemia/efectos de los fármacos
Paracetamol (PCM) overdose can cause hepatotoxicity with oxidative stress; the present study was carried out to establish the possible protective effect of olive leaves extract (OLE) on toxicity induced by paracetamol in adult male rats. Twenty four adult male rats were divided into four equal groups; co...
Acetaminofén/toxicidad,
Olea,
Estrés Oxidativo/efectos de los fármacos,
Antioxidantes/farmacología,
Oxidantes,
Extractos Vegetales/farmacología,
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control,
Medicamentos Hepatoprotectores,
Hojas de la Planta,
Extractos Vegetales/química,
Hígado/patología,
Hepatocitos/efectos de los fármacos,
Distribución Aleatoria,
Ratas Endogámicas,
Ratas Wistar
The objective of this study was to evaluate the hepatoprotective effect of the honey bee Apis mellifera ethanolic extract of the red propolis, obtained in four municipalities of the Rio Grande do Norte semi-arid region, through an in vitro evaluation of the antineoplastic potential in human hepatic carci...
ABSTRACT Objective: To determine the hepatoprotective and antioxidant effects of hydro-alcoholic extract of Prosopis farcta (P farcta) leaves on high fat diet-fed (HFDF) rats. Methods: In this experimental study, 40 male Wistar rats were divided into four groups - group 1: normal control group; group 2...
Abstract The aim of this study was to investigate in vitro antioxidant properties and in vivo protective effects of the methanol extract of the Hypericum triquetrifolium Turra (HT) seed against acute hepatotoxicity, myelotoxicity and hematotoxicity in rats induced by cyclophosphamide (CP). In order to i...
ABSTRACT Objective: Aflatoxicosis is a mycotoxicosis infection with an acute or chronic course that forms due to aflatoxins (AFs) in humans and animals. Aflatoxins primarily affect the liver and can lead to histopathological necrosis, fibrosis and hepatocarcinogenesis of the organ. This paper studied th...
