Critical role of metabotropic glutamate receptor 4 in bone marrow-derived dendritic cells in the Th17 cell differentiation and the melanogenesis of B16 cells
Braz. j. med. biol. res; 53 (4), 2020
Vitiligo is an acquired pigmentary disorder resulting from selective destruction of melanocytes. Emerging studies have suggested that T helper cell 17 (Th17) is potentially implicated in vitiligo development and progression. It was recently discovered that metabotropic glutamate receptor 4 (mGluR4) can m...
Células de la Médula Ósea/citología, Diferenciación Celular/fisiología, Células Dendríticas/citología, Citometría de Flujo, Melaninas/biosíntesis, Melanocitos/citología, Ratones Endogámicos C57BL, ARN Interferente Pequeño/inmunología, Receptores de Glutamato Metabotrópico/fisiología, Células Th17/citología, Células Th17/inmunología, Vitíligo/genética, Vitíligo/inmunología