SUMMARY OBJECTIVE: A growing volume of literature has suggested long noncoding RNAs (lncRNAs) as important players in tumor progression. In this study, we aimed to investigate the expression and prognostic value of lncRNA LINC00173 (LINC00173) in melanoma. METHODS: LINC00173 expression was measured in ...
OBJECTIVES: Malignant melanoma (MM) is an invasive tumor that poses a threat to patient health. Circular RNAs (circRNAs) are important regulators of MM carcinogenesis. In this study, we investigated the expression characteristics and biological functions of, and mechanism underlying, circ_0119872 express...
Introdução: Cerca de 5 a 10% de todos os melanomas ocorrem em famílias com predisposição hereditária. A Síndrome do Melanoma Familial (SMF) é síndrome de câncer hereditário que confere predisposição ao melanoma cutâneo e caracteriza-se pela presença de múltiplos casos de melanoma na famí...
BACKGROUND: Melanoma is one of the major types of skin cancer. The metastatic melanoma is among the most lethal forms of malignant skin tumors. We hereby aimed to characterize a novel microRNA (miR) in the metastatic melanoma model. METHODS: First, we evaluated the expression of miR-107 in melanoma cells...
El melanoma maligno es la forma más agresiva de cáncer de piel, con una tasa de mortalidad en Argentina 1997-2001 = 1.1/100 000 en varones y 0.6 en mujeres. El proto-oncogén BRAF es foco de intensa investigación, su mutación es uno de los principales promotores tumorales y pueden presentarse en 50% ...
Abstract: BACKGROUND: Approximately five to 10% of all melanomas occur in families with hereditary predisposition and the main high-risk melanoma susceptibility gene is the CDKN2A. OBJECTIVES: To describe, after a five-years study, the clinical data of patients (probands) from familial melanoma kindred...
Abstract: In the recent past years, many discoveries in the tumor microenvironment have led to changes in the management of melanoma and it is rising up hopes, specially, to those in advanced stages. FDA approved seven new drugs from 2011 to 2014. They are: Vemurafenib, Dabrafenib and Trametinib, kinases...
Background: Melanoma is a metastatic type of skin cancer that is difficult to treat and the majority of efforts are
directed to the design of new drugs. Medicinal Plants have been the primary source of medicines since life on
earth; more than 50% of existing cancer treatments is derived from plants. Bauh...
Cutaneous melanoma is a highly aggressive tumor developing from melanocytes, its incidence is increasing, and prognosis in advanced stages is daunting. New therapies have been approved during the recent years with unprecedented results, including inhibitors of MAPK/ERK pathway and immune checkpoint block...
Antineoplásicos/uso terapéutico,
Melanoma/tratamiento farmacológico,
Melanoma/secundario,
Neoplasias Cutáneas/tratamiento farmacológico,
Neoplasias Cutáneas/patología,
Antineoplásicos/farmacología,
Protocolos de Quimioterapia Combinada Antineoplásica,
Melanoma/genética,
Quinasas de Proteína Quinasa Activadas por Mitógenos/antagonistas & inhibidores,
Terapia Molecular Dirigida,
Proteínas Proto-Oncogénicas B-raf/antagonistas & inhibidores,
Neoplasias Cutáneas/genética
Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous me...
Neoplasias Encefálicas/secundario,
Melanoma/secundario,
Neoplasias Primarias Múltiples/patología,
Neoplasias Cutáneas/patología,
Neoplasias Gástricas/secundario,
Biopsia,
Neoplasias Encefálicas/genética,
Inhibidor p18 de las Quinasas Dependientes de la Ciclina/genética,
Dermoscopía,
Melanoma/genética,
Mutación,
Neoplasias Primarias Múltiples/genética,
Neoplasias Cutáneas/genética,
Neoplasias Gástricas/genética
