p19Arf sensitizes B16 melanoma cells to interferon-β delivered via mesenchymal stem cells in vitro
Braz. j. med. biol. res; 53 (3), 2020
The immune stimulatory and anti-neoplastic functions of type I interferon have long been applied for the treatment of melanoma. However, the systemic application of high levels of this recombinant protein is often met with toxicity. An approach that provides localized, yet transient, production of type I...
Línea Celular Tumoral, Proliferación Celular, Inhibidor p16 de la Quinasa Dependiente de Ciclina/administración & dosificación, Modelos Animales de Enfermedad, Terapia Genética, Interferón beta/metabolismo, Melanoma Experimental/metabolismo, Melanoma Experimental/terapia, Células Madre Mesenquimatosas/metabolismo, Ratones Endogámicos C57BL, Transducción Genética