LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Synergistic effects of dendrosomal nanocurcumin and oxaliplatin on oncogenic properties of ovarian cancer cell lines by down-expression of MMPs

BACKGROUND: Contrary to the advantageous anticancer activities of curcumin (Cur), limited bioavailability and solubility hindered its efficacy. Here, nontoxic dendrosomal nano carrier with Cur was used to overcome these problems. Despite considerable antitumor properties of Oxaliplatin (Oxa), the limitin...

Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells

Moritz, Milene Nóbrega de Oliveira; Eustáquio, Lívia Mara Santos; Micocci, Kelli Cristina; Nunes, Ana Carolina Caetano; Santos, Patty Karina dos; Vieira, Tamires de Castro; Selistre-de-Araujo, Heloísa Sobreiro.

J. venom. anim. toxins incl. trop. dis; 24 (), 2018

Background: Matrix metalloproteinases (MMPs) are key players in tumor progression, helping tumor cells to modify their microenvironment, which allows cell migration to secondary sites. The role of integrins, adhesion receptors that connect cells to the extracellular matrix, in MMP expression and activity...

Metaloproteinasa 9 de la Matriz/farmacología, Metaloproteinasa 2 de la Matriz/farmacología, Neoplasias de la Mama, Células Endoteliales, Venenos de Crotálidos/farmacología, Integrina alfa2beta1/metabolismo, Bothrops, Receptores de Colágeno, Microambiente Tumoral, Reacción en Cadena de la Polimerasa/métodos, Western Blotting/métodos, Citometría de Flujo

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