RESUMO Objetivo: Determinar se os níveis plasmáticos das metaloproteinases de matriz -2 e -9 tem associação com a mortalidade na unidade de terapia intensiva em pacientes com trauma craniencefálico grave, independentemente de lesões não cerebrais associadas. Métodos: Esta coorte prospectiva inc...
ABSTRACT In recent years, extreme attention has been focused on the role of human herpesvirus-6 (HHV-6) in multiple sclerosis (MS) pathogenesis. However, the pathogenesis of MS associated with HHV-6 infection remains unknown. In this study, we measured the serum levels of matrix metalloproteinase-2 (MMP-...
Marco Thon, Marta Susana;
Boragno Guerra, Daniela;
Rodríguez Camarot, Paola Carolina;
Mestre Cordero, Victoria;
Pereira Abreu, María Natalia;
Berasain Brandolini, Mónica Patricia;
Cadenas Levaggi, María Florencia;
Rodríguez Arzuaga, Cecilia;
Moreira Sosa, Alejandra Gabriela;
Simoff Torres, María Ximena;
Bianchi Queiruga, María Virginia;
Barindelli Denis, Anna Gabriela;
Fielitz Gentile, Pablo Federico;
Olivera Bravo, Silvia Ethel.
El consumo crónico de alcohol en Uruguay es un problema creciente, sin embargo, las determinaciones de biomarcadores consensuados no se realizan sistemáticamente ni se investigan otros marcadores potenciales. Para validar la hipótesis de que las metaloproteinasas de matriz con actividad gelatinasa son...
Estudios Transversales,
Estudios de Casos y Controles,
Estudios de Cohortes,
Método Doble Ciego,
Metaloproteinasa 2 de la Matriz/sangre,
Metaloproteinasa 9 de la Matriz/sangre,
Alcoholismo/diagnóstico,
Alcoholismo/sangre,
Alcoholismo/enzimología,
Biomarcadores/sangre,
gamma-Glutamiltransferasa/sangre,
Aspartato Aminotransferasas/sangre,
Índices de Eritrocitos,
Sensibilidad y Especificidad
Abstract Purpose: To analyze the preoperative serum matrix metalloproteinase-9 (MMP-9) levels and prognosis of patients with hilar cholangiocarcinoma (HC) undergoing radical resection. Methods: Preoperative serum MMP-9 levels in patients with HC undergoing radical resection were detected by enzyme-link...
Neoplasias de los Conductos Biliares/sangre,
Neoplasias de los Conductos Biliares/mortalidad,
Neoplasias de los Conductos Biliares/patología,
Neoplasias de los Conductos Biliares/cirugía,
Ensayo de Inmunoadsorción Enzimática,
Estimación de Kaplan-Meier,
Tumor de Klatskin/sangre,
Tumor de Klatskin/mortalidad,
Tumor de Klatskin/patología,
Tumor de Klatskin/cirugía,
Metaloproteinasa 9 de la Matriz/sangre,
Análisis Multivariante,
Invasividad Neoplásica,
Periodo Posoperatorio,
Periodo Preoperatorio,
Pronóstico,
Curva ROC,
Valores de Referencia,
Factores de Riesgo,
Factores de Tiempo
Santos, Jéssica Cavalcante dos;
Cruz, Marina Sampaio;
Bortolin, Raul Hernandes;
Oliveira, Katiene Macêdo de;
Araújo, Jéssica Nayara Góes de;
Duarte, Victor Hugo Rezende;
Silva, Ananília Medeiros Gomes da;
Santos, Isabelle Cristina Clemente dos;
Dantas, Juliana Marinho de Oliveira;
Paiva, Maria Sanali Moura de Oliveira;
Rezende, Adriana Augusto;
Hirata, Mario Hiroyuki;
Hirata, Rosario Dominguez Crespo;
Luchessi, André Ducati;
Silbiger, Vivian Nogueira.
OBJECTIVES: Inflammatory molecules play a role in the development of atherosclerosis, which is the primary origin of cardiovascular disorders. However, to the best of our knowledge, no study has attempted to investigate the relationship between these circulating molecules and the prediction of cardiovasc...
ABSTRACT Background: Gastric cancer is the 3rd most common cause of death in men and the 5th common in women worldwide. Today, surgery is the only curative therapy. Currently available advanced imaging modalities can predict R0 resection in most patients, but it can only be detected with certainty in t...
Adenocarcinoma/sangre,
Adenocarcinoma/patología,
Adenocarcinoma/cirugía,
Biomarcadores de Tumor/sangre,
Queratina-18/sangre,
Modelos Logísticos,
Metástasis Linfática/patología,
Metaloproteinasa 9 de la Matriz/sangre,
Estadificación de Neoplasias,
Valores de Referencia,
Estadísticas no Paramétricas,
Neoplasias Gástricas/sangre,
Neoplasias Gástricas/patología,
Neoplasias Gástricas/cirugía,
Inhibidor Tisular de Metaloproteinasa-1/sangre
ABSTRACT Intrahepatic cholestasis of pregnancy (ICP) is a severe liver disease uniquely occurring during pregnancy. In this study we aimed to identify novel biomarker for the diagnosis of ICP in Chinese population. 50 healthy pregnant women, 50 mild ICP patients and 48 severe ICP patients were enrolled f...
Colestasis Intrahepática/sangre,
Metaloproteinasa 2 de la Matriz/sangre,
Metaloproteinasa 9 de la Matriz/sangre,
Complicaciones del Embarazo/sangre,
Biomarcadores/sangre,
Pruebas de Función Hepática,
Estudios de Casos y Controles,
Colestasis Intrahepática/diagnóstico,
Colestasis Intrahepática/enzimología,
Complicaciones del Embarazo/enzimología,
Complicaciones del Embarazo/diagnóstico,
Reproducibilidad de los Resultados,
Índice de Severidad de la Enfermedad,
Regulación hacia Arriba,
China
Abstract Background: Childhood obesity is associated with increased risk of atherosclerosis and cardiovascular disease in adulthood. Increased intima-media thickness (IMT) of the carotid artery is linked to the initiation and progression of the chronic inflammatory processes implicated in cardiovascular...
Antropometría,
Aterosclerosis/etiología,
Biomarcadores/sangre,
Arterias Carótidas/patología,
Grosor Intima-Media Carotídeo,
Estudios de Casos y Controles,
Estudios Transversales,
Metaloproteinasa 9 de la Matriz/sangre,
Obesidad Infantil/sangre,
Obesidad Infantil/complicaciones,
Obesidad Infantil/patología,
Valores de Referencia,
Medición de Riesgo,
Factores de Riesgo,
Estadísticas no Paramétricas,
Inhibidor Tisular de Metaloproteinasa-1/sangre
Wu, Gang;
Wang, Shun;
Cheng, Mian;
Peng, Bin;
Liang, Jingjun;
Huang, He;
Jiang, Xuejun;
Zhang, Lizhi;
Yang, Bo;
Cha, Yongmei;
Jiang, Hong;
Huang, Congxin.
OBJECTIVES: This study investigated whether the serum matrix metalloproteinase-9 level is an independent predictor of recurrence after catheter ablation for persistent atrial fibrillation. METHODS: Fifty-eight consecutive patients with persistent atrial fibrillation were enrolled and underwent catheter ...
Fibrilación Atrial/enzimología,
Fibrilación Atrial/fisiopatología,
Fibrilación Atrial/cirugía,
Ablación por Catéter/métodos,
Cardioversión Eléctrica/métodos,
Metaloproteinasa 9 de la Matriz/sangre,
Análisis Multivariante,
Periodo Posoperatorio,
Valor Predictivo de las Pruebas,
Estudios Prospectivos,
Recurrencia,
Factores de Tiempo
